Drug Safety Evaluation Methods and Protocols /
| Autor Corporativo: | |
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| Outros Autores: | |
| Resumo: | XIII, 431 p. 78 illus., 4 illus. in color. text |
| Idioma: | inglês |
| Publicado em: |
Totowa, NJ :
Humana Press : Imprint: Humana,
2011.
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| Edição: | 1st ed. 2011. |
| coleção: | Methods in Molecular Biology,
691 |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1007/978-1-60761-849-2 |
| Formato: | Recurso Eletrônico Livro |
Sumário:
- Developing Combination Drugs in Preclinical Studies
- Preclinical Evaluation of Juvenile Toxicity
- Necropsy and Sampling Procedures in Rodents
- Histopathology Procedures: From Tissue Sampling to Histopathological Evaluation
- Principles and Methods of Immunohistochemistry
- Tissue Microarrays and Digital Image Analysis
- Micronucleus Assay and Labeling of Centromeres with FISH Technique
- The Use of Bacterial Repair Endonucleases in the Comet Assay
- Manual Whole-Cell Patch-Clamping of the HERG Cardiac K+ Channel
- Generation and Analysis of Transcriptomics Data
- Protocols of Two-Dimensional Difference Gel Electrophoresis (2D-DIGE) to Investigate Mechanisms of Toxicity
- Protocols and Applications of Cellular Metabolomics in Safety Studies Using Precision-Cut Tissue Slices and Carbon 13 NMR
- Statistical Analysis of Quantitative RT-PCR Results
- Evaluation of Mitochondrial Respiration in Cultured Rat Hepatocytes
- FETAX Assay for Evaluation of Developmental Toxicity
- Evaluation of Embryotoxicity Using the Zebrafish Model
- Protocols of In vitro Protein Covalent Binding Studies in Liver
- Utilization of MALDI-TOF to Determine Chemical-Protein Adduct Formation In vitro
- Utilization of LC-MS/MS Analyses to Identify Site-Specific Chemical Protein Adducts In vitro
- 1-Dimensional Western Blotting Coupled to LC-MS/MS Analysis to Identify Chemical-Adducted Proteins in Rat Urine
- Identification of Chemical Adducted Proteins in Urine by Multi-Dimensional Protein Identification Technology (LC/LC-MS/MS)
- Optimization of SELDI for Biomarker Detection in Plasma
- Differential Proteomics Incorporating iTRAQ Labelling and Multi-Dimensional Separations
- NMR and MS Methods for Metabonomics
- Absolute Quantification of Toxicological Biomarkers by Multiple Reaction Monitoring.