Pectin-calcium carbonate particles hydrogels: a tunable platform for tissue-mimetic corrosion testing of metallic implants; Journal of the Indian Chemical Society; Vol. 103, iss. 10
| Parent link: | Journal of the Indian Chemical Society.— .— Amsterdam: Elsevier B.V. Vol. 103, iss. 10.— 2026.— Article number 103050, 17 p. |
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| Summary: | Title screen The accurate in vitro assessment of biodegradable and permanent metallic implants requires test environments that replicate the complex physicochemical microenvironment of human tissues – a demand unmet by conventional liquid electrolytes. This study aims to develop and characterize pectin-based polymer gel films as physiologically relevant test media for corrosion studies of titanium alloy TA2 and magnesium alloy AZ91D, and to evaluate the influence of solvent system (deionized water vs. Ringer’s solution) and CaCO3 particle type (synthesized by direct precipitation, DPS, or nano-spray drying, NSDS) on their physicochemical and electrochemical performance. Comprehensive characterization included drying kinetics with Arrhenius activation energy analysis, swelling behavior, electrical resistance, FTIR spectroscopy, surface morphology, gravimetric weight loss, open-circuit potentiometry, and potentiodynamic polarization. The results show that CaCO3 addition reduces electrical resistance, with NSDS-derived particles yielding the lowest resistance (R_P2 < R_P3 < R_P1) due to their smaller size, uniform spherical morphology, and more extensive Ca2+ release, while DPS-derived particles provide intermediate resistance. FTIR spectroscopy reveals increased crosslinking density through Ca2+-carboxylate coordination via the egg-box mechanism, evidenced by systematic attenuation of the asymmetric carboxylate stretch at 1640 cm−1. Gels prepared with Ringer’s solution exhibit linear Arrhenius behavior with intermediate Ea (≈15 kJ mol−1), while water-based gels show two-stage kinetics with low Ea at <323 K (≈3 kJ mol−1) and high Ea at >323 K (≈26-32 kJ mol−1). In contact with AZ91D, pectin gels reduce weight loss by up to 55 % compared to liquid Ringer’s solution, shift open-circuit potentials to more noble values (by up to 400 mV), and decrease corrosion current density by approximately three orders of magnitude, promoting localized pitting rather than uniform attack – a morphology closely resembling in vivo degradation. Notably, despite exhibiting higher electrical resistance than NSDS-containing gels, DPS-containing gels provide superior corrosion protection for AZ91D due to enhanced physical barrier effects and mass transport limitation. For TA2, gels destabilize the passive film but maintain higher potentials than bulk solution. The choice of CaCO3 synthesis route (DPS vs. NSDS) provides a versatile tool to tune crosslinking, conductivity, and protective efficacy. Pectin-based hydrogels, especially those containing DPS-derived CaCO3 in Ringer’s solution, represent a promising, customizable platform for physiologically relevant in vitro corrosion testing of metallic biomedical implants Текстовый файл AM_Agreement |
| Language: | English |
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2026
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| Online Access: | https://doi.org/10.1016/j.jics.2026.103050 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=688594 |