The Effect of Tryptanthrin and Its Oxime on the Blood–Brain Barrier Permeability in Rats with Cerebral Infarction; Bulletin of Experimental Biology and Medicine; Vol. 179, iss. 2
| Parent link: | Bulletin of Experimental Biology and Medicine=Бюллетень экспериментальной биологии и медицины.— .— New York: Springer Science+Business Media LLC. Vol. 179, iss. 2.— 2025.— P. 206-210 |
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| Summary: | Title screen A comparative study of the effect of tryptanthrin and its oxime (Tr-Ox) on the blood–brain barrier (BBB) permeability was conducted in male Wistar rats with cerebral infarction (CI) modeled by intraluminal occlusion of the middle cerebral artery. In 3, 48, and 72 h after CI, extravasation of Evans blue bound to serum albumin in the cerebral hemispheres was assessed 3 h after its intravenous administration (3 ml/kg, 2% solution). Tryptanthrin and Tr-Ox were injected intraperitoneally in a dose of 10 mg/kg on the 30th minute of ischemia and then daily for 2 days. There were no significant differences in the effects of these compounds 3 and 48 h after CI. In both experimental groups, the dye concentration in the left (affected) hemisphere significantly decreased after 3 and 48 h by 30-37 and 51-54%, respectively, in comparison with the control (CI without treatment); in the right hemisphere, dye concentration decreased by 34-39% after 48 h. After 72 h, 45% reduction in Evans blue extravasation in the affected hemisphere was found only in the Tr-Ox group. The ability of tryptanthrin and Tr-Ox to reduce the BBB permeability in the CI acute period is mainly due to the anti-inflammatory effect of these compounds. The protective effect of Tr-Ox, which can affect the JNK1/3 signaling pathway, was more prolonged Текстовый файл AM_Agreement |
| Language: | English |
| Published: |
2025
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| Subjects: | |
| Online Access: | https://doi.org/10.1007/s10517-025-06459-y Статья на русском языке |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=687758 |