Tailoring the structure and phase composition of magnetoelectric nanotransducers for efficient neuromodulation under low-intensity magnetic fields; Ceramics International; Vol. 52, iss. 13, pt. A
| Parent link: | Ceramics International.— .— Oxford: Elsevier Ltd Vol. 52, iss. 13, pt. A.— 2026.— P. 21968-21987 |
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| Diğer Yazarlar: | , , , , , , , , , , , , , , , , |
| Özet: | Title screen Magnetoelectric (ME) core-shell nanoparticles (NPs) are promising for wireless neurostimulation, but achieving high ME response with biocompatible materials still remains a challenge. Herein, we report biocompatible ME core-shell MnFe2O4@Ba0.8Ca0.15Zr0.1Ti0.9O3 NPs (22 ± 4 nm) prepared using microwave-assisted hydrothermal synthesis with tailored structure and phase composition of a thin epitaxial BCZT shell (2-6 nm). Enhanced ME response and superior wireless neurostimulation performance under a low-intensity alternating magnetic field (AMF) (0-6 mT, 50 Hz) were demonstrated. The increase in the synthesis temperature (from 185 to 225 °C), alkali concentration (from 2 to 10 M), and duration (from 1 to 6 h) reduced the orthorhombic phase content while the fractions of the tetragonal (up to 63 %) and trigonal (up to 37 %) phases were increased. A synthesis temperature of 185 °C produced NPs with a partially amorphous shell and a trace Ba1.12Ti8O16-δ phase. This phase was absent in other ME NPs synthesized by reducing alkali content or reaction time. These specific structural changes, caused by the reduced synthesis temperature (185 °C), led to a drastic enhancement of the effective piezoelectric performance (18.25 ± 7.32 pm·V−1) and a more than threefold increase in the ME response (1.8 × 106 mV cm−1 Oe−1), ranking among the highest values reported for ME NPs. Consequently, neurons treated with NPs synthesized at 185 °C showed an ∼20% increase in the population of stimulated hippocampal neurons and a more than threefold enhancement in AMF-driven Ca2+ influx compared to those treated with NPs synthesized at 225 °C. Thus, the present work conclusively establishes MFO@BCZT as a validated proof-of-concept platform for magneto-neural interfacing, with a clear pathway for efficacy optimization through synthetic refinement Текстовый файл AM_Agreement |
| Dil: | İngilizce |
| Baskı/Yayın Bilgisi: |
2026
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| Konular: | |
| Online Erişim: | https://doi.org/10.1016/j.ceramint.2026.03.266 |
| Materyal Türü: | Elektronik Kitap Bölümü |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=687383 |
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| 200 | 1 | |a Tailoring the structure and phase composition of magnetoelectric nanotransducers for efficient neuromodulation under low-intensity magnetic fields |f D. A. Koptsev, P. V. Chernozem, A. O. Urakova [et al.] | |
| 203 | |a Текст |b визуальный |c электронный | ||
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| 300 | |a Title screen | ||
| 320 | |a References: 94 tit | ||
| 330 | |a Magnetoelectric (ME) core-shell nanoparticles (NPs) are promising for wireless neurostimulation, but achieving high ME response with biocompatible materials still remains a challenge. Herein, we report biocompatible ME core-shell MnFe2O4@Ba0.8Ca0.15Zr0.1Ti0.9O3 NPs (22 ± 4 nm) prepared using microwave-assisted hydrothermal synthesis with tailored structure and phase composition of a thin epitaxial BCZT shell (2-6 nm). Enhanced ME response and superior wireless neurostimulation performance under a low-intensity alternating magnetic field (AMF) (0-6 mT, 50 Hz) were demonstrated. The increase in the synthesis temperature (from 185 to 225 °C), alkali concentration (from 2 to 10 M), and duration (from 1 to 6 h) reduced the orthorhombic phase content while the fractions of the tetragonal (up to 63 %) and trigonal (up to 37 %) phases were increased. A synthesis temperature of 185 °C produced NPs with a partially amorphous shell and a trace Ba1.12Ti8O16-δ phase. This phase was absent in other ME NPs synthesized by reducing alkali content or reaction time. These specific structural changes, caused by the reduced synthesis temperature (185 °C), led to a drastic enhancement of the effective piezoelectric performance (18.25 ± 7.32 pm·V−1) and a more than threefold increase in the ME response (1.8 × 106 mV cm−1 Oe−1), ranking among the highest values reported for ME NPs. Consequently, neurons treated with NPs synthesized at 185 °C showed an ∼20% increase in the population of stimulated hippocampal neurons and a more than threefold enhancement in AMF-driven Ca2+ influx compared to those treated with NPs synthesized at 225 °C. Thus, the present work conclusively establishes MFO@BCZT as a validated proof-of-concept platform for magneto-neural interfacing, with a clear pathway for efficacy optimization through synthetic refinement | ||
| 336 | |a Текстовый файл | ||
| 371 | 0 | |a AM_Agreement | |
| 461 | 1 | |t Ceramics International |c Oxford |n Elsevier Ltd | |
| 463 | 1 | |t Vol. 52, iss. 13, pt. A |v P. 21968-21987 |d 2026 | |
| 610 | 1 | |a Magnetoelectrics | |
| 610 | 1 | |a Core-shell nanoparticles | |
| 610 | 1 | |a Hydrothermal synthesis | |
| 610 | 1 | |a Biomaterials | |
| 610 | 1 | |a Electrostimulation | |
| 610 | 1 | |a Deep brain stimulation | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 701 | 1 | |a Koptsev |b D. A. |c specialist in the field of material science |c Laboratory assistant of Tomsk Polytechnic University |f 2003- |g Danila Andreevich |9 88597 | |
| 701 | 1 | |a Chernozem |b P. V. |c specialist in the field of informatics and computer technology |c Research Engineer of Tomsk Polytechnic University |f 1997- |g Polina Viktorovna |9 22733 | |
| 701 | 1 | |a Urakova |b A. O. |c specialist in the field of material science |c Laboratory assistant of Tomsk Polytechnic University |f 2002- |g Alina Olegovna |9 88596 | |
| 701 | 1 | |a Lisitsyn |b S. A. |g Sergey Aleksandrovich | |
| 701 | 1 | |a Vagner (Wagner) |b D. V. |c physicist |c Senior Researcher of Tomsk Polytechnic University, Candidate of technical sciences |f 1990- |g Dmitry Viktorovich |9 89321 | |
| 701 | 1 | |a Kozadayeva |b M. |c chemist |c engineer of Tomsk Polytechnic University |f 1998- |g Maria |9 22899 | |
| 701 | 1 | |a Baksheev |b A. I. |c specialist in the field of material science |c Engineer of Tomsk Polytechnic University |f 2003- |g Artem Igorevich |9 89324 | |
| 701 | 1 | |a Surmeneva |b M. A. |c specialist in the field of material science |c engineer-researcher of Tomsk Polytechnic University, Associate Scientist |f 1984- |g Maria Alexandrovna |9 15966 | |
| 701 | 1 | |a Gerasimov |b E. Yu. |g Evgeny | |
| 701 | 1 | |a Amelina |b K. A. |g Kseniia | |
| 701 | 1 | |a Nosov |b G. A. |g Georgy | |
| 701 | 1 | |a Kazakova |b L. I. |g Lyubov | |
| 701 | 1 | |a Sharapova |b M. B. |c Doctor |c Engineer of Tomsk Polytechnic University |f 2003- |g Marina Borisovna |9 89326 | |
| 701 | 1 | |a Romashchenko |b A. V. |g Aleksandr Viktorovich |f 1986- |c biologist |c Associate Professor of Tomsk Polytechnic University, Candidate of biological sciences |9 88955 | |
| 701 | 1 | |a Sukhorukov |b G. B. |c chemist |c The Head of the Laboratory of Tomsk Polytechnic University, Candidate of physical and mathematical sciences |f 1969- |g Gleb Borisovich |9 20271 | |
| 701 | 1 | |a Surmenev |b R. A. |c physicist |c Associate Professor of Tomsk Polytechnic University, Senior researcher, Candidate of physical and mathematical sciences |f 1982- |g Roman Anatolievich |9 15957 | |
| 701 | 1 | |a Chernozem |b R. V. |c physicist |c Associate Professor of Tomsk Polytechnic University |f 1992- |g Roman Viktorovich |9 19499 | |
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