Tailoring the structure and phase composition of magnetoelectric nanotransducers for efficient neuromodulation under low-intensity magnetic fields; Ceramics International; Vol. 52, iss. 13, pt. A
| Parent link: | Ceramics International.— .— Oxford: Elsevier Ltd Vol. 52, iss. 13, pt. A.— 2026.— P. 21968-21987 |
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| Další autoři: | , , , , , , , , , , , , , , , , |
| Shrnutí: | Title screen Magnetoelectric (ME) core-shell nanoparticles (NPs) are promising for wireless neurostimulation, but achieving high ME response with biocompatible materials still remains a challenge. Herein, we report biocompatible ME core-shell MnFe2O4@Ba0.8Ca0.15Zr0.1Ti0.9O3 NPs (22 ± 4 nm) prepared using microwave-assisted hydrothermal synthesis with tailored structure and phase composition of a thin epitaxial BCZT shell (2-6 nm). Enhanced ME response and superior wireless neurostimulation performance under a low-intensity alternating magnetic field (AMF) (0-6 mT, 50 Hz) were demonstrated. The increase in the synthesis temperature (from 185 to 225 °C), alkali concentration (from 2 to 10 M), and duration (from 1 to 6 h) reduced the orthorhombic phase content while the fractions of the tetragonal (up to 63 %) and trigonal (up to 37 %) phases were increased. A synthesis temperature of 185 °C produced NPs with a partially amorphous shell and a trace Ba1.12Ti8O16-δ phase. This phase was absent in other ME NPs synthesized by reducing alkali content or reaction time. These specific structural changes, caused by the reduced synthesis temperature (185 °C), led to a drastic enhancement of the effective piezoelectric performance (18.25 ± 7.32 pm·V−1) and a more than threefold increase in the ME response (1.8 × 106 mV cm−1 Oe−1), ranking among the highest values reported for ME NPs. Consequently, neurons treated with NPs synthesized at 185 °C showed an ∼20% increase in the population of stimulated hippocampal neurons and a more than threefold enhancement in AMF-driven Ca2+ influx compared to those treated with NPs synthesized at 225 °C. Thus, the present work conclusively establishes MFO@BCZT as a validated proof-of-concept platform for magneto-neural interfacing, with a clear pathway for efficacy optimization through synthetic refinement Текстовый файл AM_Agreement |
| Jazyk: | angličtina |
| Vydáno: |
2026
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| Témata: | |
| On-line přístup: | https://doi.org/10.1016/j.ceramint.2026.03.266 |
| Médium: | Elektronický zdroj Kapitola |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=687383 |