Tailoring the structure of gallium-doped magnetite nanoparticles for cancer therapy; Materials Today Nano; Vol. 34

Tailoring the structure of gallium-doped magnetite nanoparticles for cancer therapy; Materials Today Nano; Vol. 34

Bibliographic Details
Parent link:	Materials Today Nano.— .— Amsterdam: Elsevier Science Publishing Company Inc. Vol. 34.— 2026.— Article number 100846, 16 p.
Other Authors:	Baksheev A. I. Artem Igorevich, Mamatova A. M. Alina Manasovna, Vagner (Wagner) D. V. Dmitry Viktorovich, Kozadayeva M. Maria, Leonova L. A. Liliya Aleksandrovna, Sharapova M. B. Marina Borisovna, Romashchenko A. V. Aleksandr Viktorovich, Lozhkomoev A. S. Aleksandr Sergeevich, Bugrova T. A. Tatjyana Aleksandrovna, Surmeneva M. A. Maria Alexandrovna, Surmenev R. A. Roman Anatolievich, Chernozem P. V. Polina Viktorovna
Summary:	Title screen The design of multifunctional magnetic nanomaterials with enhanced therapeutic performance requires precise control over composition and structure. Here, Ga-doped magnetite (GFO) nanoparticles (NPs) are engineered to integrate gallium's anticancer activity with the magnetic responsiveness of biocompatible magnetite. A comparative analysis of sol–gel and solvothermal synthesis routes reveals a strong correlation between processing parameters, structural features, and functional performance. In the sol–gel approach, tuning Ga:Fe ratio from 1:2 to 1:3 decreased crystallite size (from 12.45 ± 1.57 to 4.83 ± 2.18 nm) and microstrain (from 0.0051059 to 0.0023367) of NPs. An optimal 1:2.5 ratio yielded phase-pure spinel NPs (12.0 ± 5.8 nm) with the highest saturation magnetization (51.1 ± 1.5 emu·g−1). Higher calcination temperatures (>500 °C) induced the formation of non-magnetic impurities in GFO NPs. In the solvothermal method, increasing the synthesis temperature (from 200 to 220 °C) at a 1:5 Ga:Fe ratio produced single-phase spinel NPs (8.7 ± 2.7 nm) with reduced microstrain (from 0.007521 to 0.0058207) and superior magnetization (53.4 ± 1.6 emu·g−1). Deviations in Ga:Fe ratio or temperature led to structural distortions and reduced magnetic performance. NPs from both methods exhibited no intrinsic cytotoxicity towards fibroblasts (0–200 μg mL−1) and only modest effects on glioblastoma cells. In addition, solvothermally synthesized GFO NPs (1:5 Ga:Fe) under a low-intensity alternating magnetic field (16 mT, 90 Hz) reduced glioblastoma viability by up to 54 %. These findings highlight a synthesis-dependent strategy to combine Ga therapeutic functionality with magnetite's superparamagnetic properties for cancer treatment Текстовый файл AM_Agreement
Language:	English
Published:	2026
Subjects:	электронный ресурс труды учёных ТПУ Magnetic nanoparticles Magnetite Gallium Structure-property relationship Sol-gel synthesis Solvothermal synthesis Anti-cancer behavior
Online Access:	https://doi.org/10.1016/j.mtnano.2026.100846
Format:	Electronic Book Chapter
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=687170

Internet

https://doi.org/10.1016/j.mtnano.2026.100846