Antioxidase-mimetic artificial biotubes for anti-inflammatory healing and regeneration of vascular injury; Biomaterials; Vol. 327

Antioxidase-mimetic artificial biotubes for anti-inflammatory healing and regeneration of vascular injury

Bibliografske podrobnosti
Parent link:Biomaterials.— .— Amsterdam: Elsevier Science Publishing Company Inc.
Vol. 327.— 2026.— Article number 123790, 16 p.
Drugi avtorji: Guliyaer Aini, Jianmei Ren, Haojie Xu, Yang Gao, Tiantian Li, Lang Ma, Li Qiu, Sheremet E. S. Evgeniya Sergeevna, Shuang Li, Cheng Chong, Ma Tian, Zhao Changsheng
Izvleček:Title screen
Inflammation is a major obstacle to endothelialization, which is essential to the long-term functionality of cardiovascular implants. Developing efficient antioxidant and inflammation-modulating biotubes for endothelial repair with minimal postsurgical complications represents a compelling clinical challenge. Here, we present the design of an antioxidase-mimic modified artificial biotube (RNP) by integrating Ru cluster-anchored Ni-based metal-organic framework onto a polycaprolactone fiber scaffold. This biotube acts as a biocatalytic reactive oxygen species (ROS) scavenger, modulating the postsurgical microenvironment to suppress the inflammatory cascades and prevent postoperative adhesions efficiently. Our studies reveal that the Ni–O–Ru interface regulates the electronic structure of the Ru active site with rapid charge transfer and enhances the ROS elimination capacity of RNP. These features enable the engineered biotube to mitigate ROS-induced endothelial cell death, promote a regenerative microenvironment, and stimulate vascular regeneration. Consequently, this leads to a robust reparative effect on rat injured arteries. These findings highlight the biocatalytic properties of RNP, offering a promising strategy for developing ROS-scavenging and anti-inflammatory biotubes for vascular repair and the treatment of various oxidative stress-related diseases
Текстовый файл
AM_Agreement
Jezik:angleščina
Izdano: 2026
Teme:
Antioxidase-mimic
Artificial grafts
Anti-Inflammation
Angiogenesis promotion
Vascular injury
электронный ресурс
труды учёных ТПУ
Online dostop:https://doi.org/10.1016/j.biomaterials.2025.123790
Format: Elektronski Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=684472

Podobne knjige/članki

Podobne knjige/članki