Antioxidase-mimetic artificial biotubes for anti-inflammatory healing and regeneration of vascular injury
| Parent link: | Biomaterials.— .— Amsterdam: Elsevier Science Publishing Company Inc. Vol. 327.— 2026.— Article number 123790, 16 p. |
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| Other Authors: | , , , , , , , , , , , |
| Summary: | Title screen Inflammation is a major obstacle to endothelialization, which is essential to the long-term functionality of cardiovascular implants. Developing efficient antioxidant and inflammation-modulating biotubes for endothelial repair with minimal postsurgical complications represents a compelling clinical challenge. Here, we present the design of an antioxidase-mimic modified artificial biotube (RNP) by integrating Ru cluster-anchored Ni-based metal-organic framework onto a polycaprolactone fiber scaffold. This biotube acts as a biocatalytic reactive oxygen species (ROS) scavenger, modulating the postsurgical microenvironment to suppress the inflammatory cascades and prevent postoperative adhesions efficiently. Our studies reveal that the Ni–O–Ru interface regulates the electronic structure of the Ru active site with rapid charge transfer and enhances the ROS elimination capacity of RNP. These features enable the engineered biotube to mitigate ROS-induced endothelial cell death, promote a regenerative microenvironment, and stimulate vascular regeneration. Consequently, this leads to a robust reparative effect on rat injured arteries. These findings highlight the biocatalytic properties of RNP, offering a promising strategy for developing ROS-scavenging and anti-inflammatory biotubes for vascular repair and the treatment of various oxidative stress-related diseases Текстовый файл AM_Agreement |
| Language: | English |
| Published: |
2026
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| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.biomaterials.2025.123790 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=684472 |