Aerobic Oxidation of Imidazolines to 2-Arylimidazoles Using CuSO4∙H2O as a Catalyst

Bibliographic Details
Parent link:Synthesis.— .— New-York: Thieme
Vol. 57, iss. 23.— 2025.— P. 3611-3616
Other Authors: Myachina K. A. Kristina Alekseevna, Semenov A. V. Artem Valerjevich, Shurikov M. K. Matvey Konstantinovich, Dar’in D. V. Dmitry, Baykov S. V. Sergey Valentinovich, Yusubov M. S. Mekhman Suleiman-Ogly (Suleimanovich), Soldatova N. S. Nataliya Sergeevna, Postnikov P. S. Pavel Sergeevich
Summary:Title screen
midazoles are considered the merit heterocyclic moiety in medicinal chemistry and drug design. Here, we report on a convenient method for the aerobic oxidation of imidazolines under mild conditions using the cheap and available CuSO4∙5H2O as the catalyst. The proposed method allows one to prepare 2-arylimidazoles bearing electron-donating and -withdrawing groups in good and quantitative yields. The developed procedure is applicable for the preparation of labile and oxidation-intolerant heterocyclic moieties
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Published: 2025
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Online Access:https://doi.org/10.1055/a-2705-5409
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=683317