Multiscale design of an additively manufactured Ti–Nb alloy with nanostructured Sr-substituted hydroxyapatite coating for bone tissue engineering

Multiscale design of an additively manufactured Ti–Nb alloy with nanostructured Sr-substituted hydroxyapatite coating for bone tissue engineering

書目詳細資料
Parent link:Ceramics International.— .— Amsterdam: Elsevier Science Publishing Company Inc.
Vol. 51, iss. 25, pt. C.— 2025.— P. 46323-46342
其他作者: Kozadayeva M. Maria, Khrapov D. Dmitriy, Grubova I. Yu. Irina Yurievna, Vladesku A. Alina, Anorin V. E. Vitaly Evgenjevich, Cotrut C. M. Cosmin, Loukelis K. Konstantinos, Dinu M. Mihaela, Chatzinikolaidou M. Maria, Kraus F. Florian, Noll F. Frank, Kahler Ph. Philipp, Koptyug A. V. Andrey, Surmenev R. A. Roman Anatolievich, Surmeneva M. A. Maria Alexandrovna
總結:Title screen
Orthopedic implant design increasingly aims to reduce the elastic modulus mismatch with bone and to mimic the native extracellular environment. However, achieving reliable osseointegration still remains a challenge. Herein, we report for the first time the fabrication and functionalization of Ti–xNb gyroid scaffolds with controlled porosity from pre-alloyed powders with different niobium content (x = 42 or 56 wt%) using powder bed fusion electron beam melting (PBF–EB) followed by strontium-substituted hydroxyapatite coating (Sr–HA) deposition via RF magnetron sputtering. Prior to coating, an optimized acid etching protocol effectively removed non-melted surface particles. Sr–HA coatings were initially deposited on flat Ti–Nb substrates to refine deposition parameters and facilitate detailed characterization using SEM, AFM, XRD, XPS, wettability measurements, and corrosion resistance testing in simulated body fluid. The resulting nanostructured, granular Sr–HA coatings (∼1000 nm thick) significantly improved both corrosion resistance and surface hydrophobicity. These coatings were subsequently applied to the gyroid scaffolds. In vitro studies assessing cytocompatibility, alkaline phosphatase (ALP) activity, calcium mineralization, and extracellular matrix production (collagen and glycosaminoglycans) revealed that the Sr–HA-coated Ti–xNb scaffolds substantially enhanced cell proliferation, nearly doubled ALP activity, promoted mineral deposition, and significantly increased collagen secretion compared to uncoated controls. This integrated approach highlights the potential of multiscale material design — combining architected porosity with nanoscale surface functionalization — to advance the development of next-generation load-bearing implants with superior osteointegration capabilities
Текстовый файл
AM_Agreement
語言:英语
出版: 2025
主題:
Bioactive coating
RF magnetron sputtering
Sr-substituted hydroxyapatite
Additive manufacturing
Biomedical alloy
электронный ресурс
труды учёных ТПУ
在線閱讀:https://doi.org/10.1016/j.ceramint.2025.07.339
格式: 電子 Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=682225

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