Multiscale design of an additively manufactured Ti–Nb alloy with nanostructured Sr-substituted hydroxyapatite coating for bone tissue engineering
| Parent link: | Ceramics International.— .— Amsterdam: Elsevier Science Publishing Company Inc. Vol. 51, iss. 25, pt. C.— 2025.— P. 46323-46342 |
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| Autres auteurs: | , , , , , , , , , , , , , , |
| Résumé: | Title screen Orthopedic implant design increasingly aims to reduce the elastic modulus mismatch with bone and to mimic the native extracellular environment. However, achieving reliable osseointegration still remains a challenge. Herein, we report for the first time the fabrication and functionalization of Ti–xNb gyroid scaffolds with controlled porosity from pre-alloyed powders with different niobium content (x = 42 or 56 wt%) using powder bed fusion electron beam melting (PBF–EB) followed by strontium-substituted hydroxyapatite coating (Sr–HA) deposition via RF magnetron sputtering. Prior to coating, an optimized acid etching protocol effectively removed non-melted surface particles. Sr–HA coatings were initially deposited on flat Ti–Nb substrates to refine deposition parameters and facilitate detailed characterization using SEM, AFM, XRD, XPS, wettability measurements, and corrosion resistance testing in simulated body fluid. The resulting nanostructured, granular Sr–HA coatings (∼1000 nm thick) significantly improved both corrosion resistance and surface hydrophobicity. These coatings were subsequently applied to the gyroid scaffolds. In vitro studies assessing cytocompatibility, alkaline phosphatase (ALP) activity, calcium mineralization, and extracellular matrix production (collagen and glycosaminoglycans) revealed that the Sr–HA-coated Ti–xNb scaffolds substantially enhanced cell proliferation, nearly doubled ALP activity, promoted mineral deposition, and significantly increased collagen secretion compared to uncoated controls. This integrated approach highlights the potential of multiscale material design — combining architected porosity with nanoscale surface functionalization — to advance the development of next-generation load-bearing implants with superior osteointegration capabilities Текстовый файл AM_Agreement |
| Langue: | anglais |
| Publié: |
2025
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| Sujets: | |
| Accès en ligne: | https://doi.org/10.1016/j.ceramint.2025.07.339 |
| Format: | Électronique Chapitre de livre |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=682225 |