Innovative Technology of the Self-Emulsifying Drug Delivery System of the Anticonvulsant Galodif

Innovative Technology of the Self-Emulsifying Drug Delivery System of the Anticonvulsant Galodif

Bibliographic Details
Parent link:Russian Journal of Bioorganic Chemistry.— .— New York: Springer Science+Business Media LLC
Vol. 49, Suppl. 1.— 2023.— P. 8-12
Other Authors: Kuksenok V. Yu. Vera Yurievna, Shtrykova V. V. Viktoriya Viktorovna, Filimonov V. D. Viktor Dmitrievich, Shushpanova T. V. Tamara Vladimirovna, Bokhan N. A. Nikolay Aleksandrovich, Seilerova L. Lenka, Kratokhvil B. Bogumil, Sieberova V. Veronika
Summary:Title screen
Galodif (1-((3-chlorophenyl)(phenyl)methyl)urea) is an anticonvulsant that can also be used in the treatment of alcohol addiction. However, galodif is practically insoluble in water, which significantly limits its use for therapeutic purposes. It is known that good water solubility improves the bioavailability of pharmaceuticals, which ensures a reduction in the applied dose and a decrease in possible side and undesirable effects of the drug. In this paper, a method of solubilization of galodif in water using a self-emulsifying drug delivery system (SEDDS) is proposed. The developed pharmacological compositions consist of ingredients that are available and widely used in pharmacy. The use of gelatin capsules with developed SEDDS increases the solubility of galodif in water more than 80% compared to its tablet form. An increase in the dissolution rate of the drug with SEDDS in the intestinal environment has been shown
Текстовый файл
AM_Agreement
Published: 2023
Subjects:
galodif
benzhydryl ureas
anticonvulsants
self-emulsifying drug delivery system
электронный ресурс
труды учёных ТПУ
Online Access:https://doi.org/10.1134/S1068162023080022
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=680152

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