Innovative Technology of the Self-Emulsifying Drug Delivery System of the Anticonvulsant Galodif
| Parent link: | Russian Journal of Bioorganic Chemistry.— .— New York: Springer Science+Business Media LLC Vol. 49, Suppl. 1.— 2023.— P. 8-12 |
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| Other Authors: | , , , , , , , |
| Summary: | Title screen Galodif (1-((3-chlorophenyl)(phenyl)methyl)urea) is an anticonvulsant that can also be used in the treatment of alcohol addiction. However, galodif is practically insoluble in water, which significantly limits its use for therapeutic purposes. It is known that good water solubility improves the bioavailability of pharmaceuticals, which ensures a reduction in the applied dose and a decrease in possible side and undesirable effects of the drug. In this paper, a method of solubilization of galodif in water using a self-emulsifying drug delivery system (SEDDS) is proposed. The developed pharmacological compositions consist of ingredients that are available and widely used in pharmacy. The use of gelatin capsules with developed SEDDS increases the solubility of galodif in water more than 80% compared to its tablet form. An increase in the dissolution rate of the drug with SEDDS in the intestinal environment has been shown Текстовый файл AM_Agreement |
| Published: |
2023
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| Subjects: | |
| Online Access: | https://doi.org/10.1134/S1068162023080022 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=680152 |