Innovative Technology of the Self-Emulsifying Drug Delivery System of the Anticonvulsant Galodif; Russian Journal of Bioorganic Chemistry; Vol. 49, Suppl. 1
| Parent link: | Russian Journal of Bioorganic Chemistry.— .— New York: Springer Science+Business Media LLC Vol. 49, Suppl. 1.— 2023.— P. 8-12 |
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| Kolejni autorzy: | , , , , , , , |
| Streszczenie: | Title screen Galodif (1-((3-chlorophenyl)(phenyl)methyl)urea) is an anticonvulsant that can also be used in the treatment of alcohol addiction. However, galodif is practically insoluble in water, which significantly limits its use for therapeutic purposes. It is known that good water solubility improves the bioavailability of pharmaceuticals, which ensures a reduction in the applied dose and a decrease in possible side and undesirable effects of the drug. In this paper, a method of solubilization of galodif in water using a self-emulsifying drug delivery system (SEDDS) is proposed. The developed pharmacological compositions consist of ingredients that are available and widely used in pharmacy. The use of gelatin capsules with developed SEDDS increases the solubility of galodif in water more than 80% compared to its tablet form. An increase in the dissolution rate of the drug with SEDDS in the intestinal environment has been shown Текстовый файл AM_Agreement |
| Język: | angielski |
| Wydane: |
2023
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| Hasła przedmiotowe: | |
| Dostęp online: | https://doi.org/10.1134/S1068162023080022 |
| Format: | Elektroniczne Rozdział |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=680152 |
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| 200 | 1 | |a Innovative Technology of the Self-Emulsifying Drug Delivery System of the Anticonvulsant Galodif |f V. U. Kuksenok, V. V. Shtrykova, V. D. Filimonov [et al.] | |
| 283 | |a online_resource |2 RDAcarrier | ||
| 300 | |a Title screen | ||
| 320 | |a References: 29 tit | ||
| 330 | |a Galodif (1-((3-chlorophenyl)(phenyl)methyl)urea) is an anticonvulsant that can also be used in the treatment of alcohol addiction. However, galodif is practically insoluble in water, which significantly limits its use for therapeutic purposes. It is known that good water solubility improves the bioavailability of pharmaceuticals, which ensures a reduction in the applied dose and a decrease in possible side and undesirable effects of the drug. In this paper, a method of solubilization of galodif in water using a self-emulsifying drug delivery system (SEDDS) is proposed. The developed pharmacological compositions consist of ingredients that are available and widely used in pharmacy. The use of gelatin capsules with developed SEDDS increases the solubility of galodif in water more than 80% compared to its tablet form. An increase in the dissolution rate of the drug with SEDDS in the intestinal environment has been shown | ||
| 336 | |a Текстовый файл | ||
| 371 | 0 | |a AM_Agreement | |
| 461 | 1 | |t Russian Journal of Bioorganic Chemistry |c New York |n Springer Science+Business Media LLC | |
| 463 | 1 | |t Vol. 49, Suppl. 1 |v P. 8-12 |d 2023 | |
| 610 | 1 | |a galodif | |
| 610 | 1 | |a benzhydryl ureas | |
| 610 | 1 | |a anticonvulsants | |
| 610 | 1 | |a self-emulsifying drug delivery system | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 701 | 1 | |a Kuksenok |b V. Yu. |c chemist |c Senior Lecturer of Tomsk Polytechnic University, Candidate of Chemical Sciences |f 1989- |g Vera Yurievna |9 16412 | |
| 701 | 1 | |a Shtrykova |b V. V. |c chemist |c Associate professor of Tomsk Polytechnic University, Candidate of chemical sciences |f 1962- |g Viktoriya Viktorovna |9 15959 | |
| 701 | 1 | |a Filimonov |b V. D. |c Russian chemist |c Professor of the TPU |f 1945- |g Viktor Dmitrievich |9 12127 | |
| 701 | 1 | |a Shushpanova |b T. V. |g Tamara Vladimirovna | |
| 701 | 1 | |a Bokhan |b N. A. |g Nikolay Aleksandrovich | |
| 701 | 1 | |a Seilerova |b L. |g Lenka | |
| 701 | 1 | |a Kratokhvil |b B. |g Bogumil | |
| 701 | 1 | |a Sieberova |b V. |g Veronika | |
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| 856 | 4 | |u https://doi.org/10.1134/S1068162023080022 |z https://doi.org/10.1134/S1068162023080022 | |
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