Halonal, an original benzoylated phenobarbital derivative anticonvulsant: in vivo evaluation, chemometric and molecular docking studies of enantiomers; Mendeleev Communications; Vol. 34, iss. 6

Halonal, an original benzoylated phenobarbital derivative anticonvulsant: in vivo evaluation, chemometric and molecular docking studies of enantiomers; Mendeleev Communications; Vol. 34, iss. 6

Dades bibliogràfiques
Parent link:	Mendeleev Communications.— .— Amsterdam: Elsevier Science Publishing Company Inc. Vol. 34, iss. 6.— 2024.— P. 854-858
Altres autors:	Shushpanova T. V. Tamara Vladimirovna, Bokhan N. A. Nikolay Aleksandrovich, Slepchenko G. B. Galina Borisovna, Markova E. V. Evgeniya Valerjevna, Shushpanova O. V. Olga Vladimirovna, Smirnova I. N. Irina Nikolaevna, Zaytsev A. A. Aleksey Aleksandrovich, Kolomiets N. E. Nataljya Eduardovna, Kuksenok V. Yu. Vera Yurievna, Filimonov V. D. Viktor Dmitrievich
Sumari:	An original phenobarbital anticonvulsant Halonal, 5-ethyl-1-(2-fluorobenzoyl)-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione, stimulated the cellular immune and the humoral response in long-term alcoholized male (CBAxC57Bl/6) F1 mice to the level of healthy animals. Voltammetry was found to be suitable for determination of Halonal R/S-enantiomeric ratio, which was exemplified on the authentic sample with the R/S-composition of 40:60. Molecular docking (Schrödinger program, Glide) showed that Halonal behaved as a benzonal derivative interacting with GABAAR via the BARB binding site, with S-Halonal having higher similarity score than its R-enantiomer because of a different orientation of the 2-fluorobenzoyl substituent Текстовый файл AM_Agreement
Idioma:	anglès
Publicat:	2024
Matèries:	электронный ресурс труды учёных ТПУ
Accés en línia:	https://doi.org/10.1016/j.mencom.2024.10.027
Format:	Electrònic Capítol de llibre
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=679558

Ítems similars

A novel urea derivative anticonvulsant: In vivo biological evaluation, radioreceptor analysis of GABAA receptors and molecular docking studies of enantiomers; Mendeleev Communications; Vol. 33, iss. 4
Publicat: (2023)

Electrochemical characterization and voltammetric determination of benzoyl derivatives of phenobarbital using glassy carbon electrode; Electroanalysis; Vol. 31, iss. 8
Publicat: (2019)

Chemometrics and species identification
Publicat: (Berlin, Springer-Verlag, 1987)

Hickory Dickory Dock
per: Кристи (Вестмакотт) А. (М.) Агата (Мэри)
Publicat: (Москва, Айрис-Пресс, 2007)

Protein-Protein Docking Methods and Protocols /
Publicat: (2024)

Docking Screens for Drug Discovery
Publicat: (2019)

Dft calculations of naphthoquinone fluorosulfate derivatives with potential cytotoxic activity; Mendeleev 2019
Publicat: (2019)

Halon 1301 synthesis by using fluoroxidants; IFOST 2012; Vol. 1
Publicat: (2012)

Original Anticonvulsant Urea Derivative Alters the Properties of Benzodiazepine Receptors Central and Peripheral Types in the Cerebral Cortex of Heavy Drinkers Rats; Journal of Alcoholism & Drug Dependence; Vol. 4, iss. 2
Publicat: (2016)

Composition of petroleum asphaltenes derived from ruthenium-catalyzed oxidation; Mendeleev Communications; Vol. 32, iss. 1
Publicat: (2022)

Inducers of the phenobarbital type (a review); Pharmaceutical Chemistry Journal; Vol. 29, iss. 3
Publicat: (1995)

Colorimetric sensor for the determination of low-molecular-weight heparin; Mendeleev Communications; Vol. 27, iss. 4
per: Gavrilenko M. A. Mikhail Alekseevich
Publicat: (2017)

In Vivo Neuromethods
Publicat: (1998)

DNA Damage Detection In Situ, Ex Vivo, and In Vivo Methods and Protocols /
Publicat: (2011)

Synthetic anticonvulsants, antehypoxants, and inducers of the hepatic monooxygenase system based on amides and ureas; II; Synthesis, anticonvulsant, antihypoxic, and enzyme-inducing properties of N-trifluoroacetyl derivatives of benzhydrylamines; Pharmaceutical Chemistry Journal; Vol. 26, iss. 11
Publicat: (1993)

In Vivo Neuropharmacology and Neurophysiology
Publicat: (2017)

In Vivo Fluorescence Imaging Methods and Protocols /
Publicat: (2016)

In vivo NMR Imaging Methods and Protocols /
Publicat: (2011)

Mild and General Protocol for Selective Deacetylation of Acetyl/Benzoyl-Protected Carbohydrates; Journal of Organic Chemistry; Vol. 89, iss.14
Publicat: (2025)

Effect of Chemically Modified Carbon-Coated Iron Nanoparticles on the Structure of Human Atherosclerotic Plaques Ex Vivo and on Adipose Tissue in Chronic Experiment In Vivo; International Journal of Molecular Sciences; Vol. 23, iss. 15
Publicat: (2022)

Immunotoxicity Study of Cucurbit[n]urils (n = 6, 7, 8) and Modeling of Interaction with Some Monocyte Receptors by a Molecular Docking Method; Molecules; Vol. 30, iss. 10
Publicat: (2025)

Determination of fluorine composition by gas chromatography; Mendeleev 2021
Publicat: (2021)

Atomic structure and Mendeleev’s Periodic System of chemical elements tutorial
per: Starodubets Е.
Publicat: (Казань, КНИТУ, 2019)

Advanced Cell and Molecular Techniques Protocols for In Vitro and In Vivo Studies /
per: Arunachalam, Karuppusamy, et al.
Publicat: (2025)

Resolution of the overlapping peaks in the case of linear sweep anodic stripping voltammetry via curve fitting; Chemometrics and Intelligent Laboratory Systems; Vol. 73, iss. 1: 8th Scandinavian Symposium on Chemometrics (SSC8), Mariehamn, Aland, Finland 14-18 June 2003
Publicat: (2004)

Kinetic modeling of light hydrocarbon zeoforming process; Mendeleev 2021
per: Altynov A. A. Andrey Andreevich
Publicat: (2021)

Arenediazonium triflates for polylactic acid surface modification; Mendeleev 2019
per: Kataeva V. A.
Publicat: (2019)

Derive
per: Половко А. М. Анатолий Михайлович
Publicat: (СПб., БХВ-Петербург, 2005)

Synthetic anticonvulsants, antihypoxic agents, and inducers of the liver monooxygenase system; XIX; The synthesis, anticonvulsive, and antihypoxic properties of benzhydrylamine carboxylates; Pharmaceutical Chemistry Journal; Vol. 28, iss. 3
Publicat: (1994)

Synthetic anticonvulsants, antihypoxics, and liver monooxygenase system inducers based on amides and urea; IV; Antihypoxic activity of benzhydrylurea and its haloid derivatives; Pharmaceutical Chemistry Journal; Vol. 27, iss. 4
Publicat: (1993)

Treatment of Alcoholic Patients Using Anticonvulsant Urea Derivative Influences the Metabolism of Neuro-active Steroid Hormones - The System of Stress Markers; Journal of Addiction Research & Therapy; Vol. 7, iss. 2
Publicat: (2016)

Synthesis, Antibacterial Properties and Molecular Docking Studies of Nitrogen Substituted 9-(((4X-But-2-ynyloxy)methyl)-1,2,3-triazolyl)–Cinchona Alkaloid Conjugates; Molecules; Vol. 30, iss. 22
Publicat: (2025)

The original anticonvulsant meta-Cl-benzhydrylurea (m-CL-BHM) induces of the liver monooxygenase system and stimulates the neuroimmune response in behavioral disorders of alcoholic origin; European Psychiatry; Vol. 65, Special iss. S1 : Abstracts of the 30th European Congress of Psychiatry, June 2022
Publicat: (2022)

The iron (III) oxide processing from the pyrite cinders; Mendeleev- 2015
per: Smorokov A. A. Andrey Arkadievich
Publicat: (2015)

Influence of unsaturation petroleum resin on the content of epoxy groups; Mendeleev- 2015
per: Ustimenko Yu. P. Yuliya Pavlovna
Publicat: (2015)

New syntheses of bis(2-pyridylmethyl)amino acid; Mendeleev- 2015
per: Kulibaba E. V. Ekaterina Vladimirovna
Publicat: (2015)

Synthetic anticonvulsants, antihypoxic agents, and liver monooxygenase inducers based on amides and urea; 3; Synthesis and anticonvulsive and antihypoxic activities of cyclohexylalkoxynaphthylmethylureas; Pharmaceutical Chemistry Journal; Vol. 27, iss. 3
Publicat: (1993)

In Vivo Cellular Imaging Using Fluorescent Proteins Methods and Protocols /
Publicat: (2012)

Origins and Originality in Family Therapy and Systemic Practice
Publicat: (2016)

Derivatives Options and Futures /
per: Ernst, Dietmar, et al.
Publicat: (2025)