Halonal, an original benzoylated phenobarbital derivative anticonvulsant: in vivo evaluation, chemometric and molecular docking studies of enantiomers; Mendeleev Communications; Vol. 34, iss. 6

Halonal, an original benzoylated phenobarbital derivative anticonvulsant: in vivo evaluation, chemometric and molecular docking studies of enantiomers; Mendeleev Communications; Vol. 34, iss. 6

Bibliographic Details
Parent link:	Mendeleev Communications.— .— Amsterdam: Elsevier Science Publishing Company Inc. Vol. 34, iss. 6.— 2024.— P. 854-858
Other Authors:	Shushpanova T. V. Tamara Vladimirovna, Bokhan N. A. Nikolay Aleksandrovich, Slepchenko G. B. Galina Borisovna, Markova E. V. Evgeniya Valerjevna, Shushpanova O. V. Olga Vladimirovna, Smirnova I. N. Irina Nikolaevna, Zaytsev A. A. Aleksey Aleksandrovich, Kolomiets N. E. Nataljya Eduardovna, Kuksenok V. Yu. Vera Yurievna, Filimonov V. D. Viktor Dmitrievich
Summary:	An original phenobarbital anticonvulsant Halonal, 5-ethyl-1-(2-fluorobenzoyl)-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione, stimulated the cellular immune and the humoral response in long-term alcoholized male (CBAxC57Bl/6) F1 mice to the level of healthy animals. Voltammetry was found to be suitable for determination of Halonal R/S-enantiomeric ratio, which was exemplified on the authentic sample with the R/S-composition of 40:60. Molecular docking (Schrödinger program, Glide) showed that Halonal behaved as a benzonal derivative interacting with GABAAR via the BARB binding site, with S-Halonal having higher similarity score than its R-enantiomer because of a different orientation of the 2-fluorobenzoyl substituent Текстовый файл AM_Agreement
Language:	English
Published:	2024
Subjects:	электронный ресурс труды учёных ТПУ
Online Access:	https://doi.org/10.1016/j.mencom.2024.10.027
Format:	Electronic Book Chapter
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=679558

Internet

https://doi.org/10.1016/j.mencom.2024.10.027