Halonal, an original benzoylated phenobarbital derivative anticonvulsant: in vivo evaluation, chemometric and molecular docking studies of enantiomers; Mendeleev Communications; Vol. 34, iss. 6

Halonal, an original benzoylated phenobarbital derivative anticonvulsant: in vivo evaluation, chemometric and molecular docking studies of enantiomers; Mendeleev Communications; Vol. 34, iss. 6

Dades bibliogràfiques
Parent link:	Mendeleev Communications.— .— Amsterdam: Elsevier Science Publishing Company Inc. Vol. 34, iss. 6.— 2024.— P. 854-858
Altres autors:	Shushpanova T. V. Tamara Vladimirovna, Bokhan N. A. Nikolay Aleksandrovich, Slepchenko G. B. Galina Borisovna, Markova E. V. Evgeniya Valerjevna, Shushpanova O. V. Olga Vladimirovna, Smirnova I. N. Irina Nikolaevna, Zaytsev A. A. Aleksey Aleksandrovich, Kolomiets N. E. Nataljya Eduardovna, Kuksenok V. Yu. Vera Yurievna, Filimonov V. D. Viktor Dmitrievich
Sumari:	An original phenobarbital anticonvulsant Halonal, 5-ethyl-1-(2-fluorobenzoyl)-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione, stimulated the cellular immune and the humoral response in long-term alcoholized male (CBAxC57Bl/6) F1 mice to the level of healthy animals. Voltammetry was found to be suitable for determination of Halonal R/S-enantiomeric ratio, which was exemplified on the authentic sample with the R/S-composition of 40:60. Molecular docking (Schrödinger program, Glide) showed that Halonal behaved as a benzonal derivative interacting with GABAAR via the BARB binding site, with S-Halonal having higher similarity score than its R-enantiomer because of a different orientation of the 2-fluorobenzoyl substituent Текстовый файл AM_Agreement
Idioma:	anglès
Publicat:	2024
Matèries:	электронный ресурс труды учёных ТПУ
Accés en línia:	https://doi.org/10.1016/j.mencom.2024.10.027
Format:	Electrònic Capítol de llibre
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=679558

Internet

https://doi.org/10.1016/j.mencom.2024.10.027