Halonal, an original benzoylated phenobarbital derivative anticonvulsant: in vivo evaluation, chemometric and molecular docking studies of enantiomers; Mendeleev Communications; Vol. 34, iss. 6
| Parent link: | Mendeleev Communications.— .— Amsterdam: Elsevier Science Publishing Company Inc. Vol. 34, iss. 6.— 2024.— P. 854-858 |
|---|---|
| Beste egile batzuk: | , , , , , , , , , |
| Gaia: | An original phenobarbital anticonvulsant Halonal, 5-ethyl-1-(2-fluorobenzoyl)-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione, stimulated the cellular immune and the humoral response in long-term alcoholized male (CBAxC57Bl/6) F1 mice to the level of healthy animals. Voltammetry was found to be suitable for determination of Halonal R/S-enantiomeric ratio, which was exemplified on the authentic sample with the R/S-composition of 40:60. Molecular docking (Schrödinger program, Glide) showed that Halonal behaved as a benzonal derivative interacting with GABAAR via the BARB binding site, with S-Halonal having higher similarity score than its R-enantiomer because of a different orientation of the 2-fluorobenzoyl substituent Текстовый файл AM_Agreement |
| Hizkuntza: | ingelesa |
| Argitaratua: |
2024
|
| Gaiak: | |
| Sarrera elektronikoa: | https://doi.org/10.1016/j.mencom.2024.10.027 |
| Formatua: | Baliabide elektronikoa Liburu kapitulua |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=679558 |
MARC
| LEADER | 00000naa0a2200000 4500 | ||
|---|---|---|---|
| 001 | 679558 | ||
| 005 | 20250408101008.0 | ||
| 090 | |a 679558 | ||
| 100 | |a 20250408d2024 k||y0rusy50 ba | ||
| 101 | 0 | |a eng | |
| 102 | |a NL | ||
| 135 | |a drcn ---uucaa | ||
| 181 | 0 | |a i |b e | |
| 182 | 0 | |a b | |
| 183 | 0 | |a cr |2 RDAcarrier | |
| 200 | 1 | |a Halonal, an original benzoylated phenobarbital derivative anticonvulsant: in vivo evaluation, chemometric and molecular docking studies of enantiomers |f Tamara V. Shushpanova, Nikolay A. Bokhan, Galina B. Slepchenko [et al.] | |
| 203 | |a Текст |b визуальный |c электронный | ||
| 283 | |a online_resource |2 RDAcarrier | ||
| 320 | |a References: 25 tit | ||
| 330 | |a An original phenobarbital anticonvulsant Halonal, 5-ethyl-1-(2-fluorobenzoyl)-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione, stimulated the cellular immune and the humoral response in long-term alcoholized male (CBAxC57Bl/6) F1 mice to the level of healthy animals. Voltammetry was found to be suitable for determination of Halonal R/S-enantiomeric ratio, which was exemplified on the authentic sample with the R/S-composition of 40:60. Molecular docking (Schrödinger program, Glide) showed that Halonal behaved as a benzonal derivative interacting with GABAAR via the BARB binding site, with S-Halonal having higher similarity score than its R-enantiomer because of a different orientation of the 2-fluorobenzoyl substituent | ||
| 336 | |a Текстовый файл | ||
| 371 | 0 | |a AM_Agreement | |
| 461 | 1 | |t Mendeleev Communications |c Amsterdam |n Elsevier Science Publishing Company Inc. | |
| 463 | 1 | |t Vol. 34, iss. 6 |v P. 854-858 |d 2024 | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 701 | 1 | |a Shushpanova |b T. V. |g Tamara Vladimirovna | |
| 701 | 1 | |a Bokhan |b N. A. |g Nikolay Aleksandrovich | |
| 701 | 1 | |a Slepchenko |b G. B. |c Chemist |c Professor of Tomsk Polytechnic University, Doctor of chemical sciences |f 1956- |g Galina Borisovna |9 16858 | |
| 701 | 1 | |a Markova |b E. V. |g Evgeniya Valerjevna | |
| 701 | 1 | |a Shushpanova |b O. V. |g Olga Vladimirovna | |
| 701 | 1 | |a Smirnova |b I. N. |g Irina Nikolaevna | |
| 701 | 1 | |a Zaytsev |b A. A. |g Aleksey Aleksandrovich | |
| 701 | 1 | |a Kolomiets |b N. E. |g Nataljya Eduardovna | |
| 701 | 1 | |a Kuksenok |b V. Yu. |c chemist |c Senior Lecturer of Tomsk Polytechnic University, Candidate of Chemical Sciences |f 1989- |g Vera Yurievna |9 16412 | |
| 701 | 1 | |a Filimonov |b V. D. |c Russian chemist |c Professor of the TPU |f 1945- |g Viktor Dmitrievich |9 12127 | |
| 801 | 0 | |a RU |b 63413507 |c 20250408 | |
| 850 | |a 63413507 | ||
| 856 | 4 | |u https://doi.org/10.1016/j.mencom.2024.10.027 |z https://doi.org/10.1016/j.mencom.2024.10.027 | |
| 942 | |c CF | ||