An N-Acetyl-L-Cysteine Impedance Sensor for Assessing Antioxidant Activity against Hydroxyl Radicals; Journal of Analytical Chemistry; Vol. 79, iss. 6
| Parent link: | Journal of Analytical Chemistry.— .— New York: Springer Science+Business Media LLC. Vol. 79, iss. 6.— 2024.— P. 663–670 |
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| Corporate Author: | |
| Other Authors: | , , , , |
| Summary: | Title screen The hydroxyl radical is the most aggressive and dangerous product of incomplete oxygen reduction in a body, making its determination and the effect of various antioxidants on the inhibition of OH radicals a pertinent task. We propose an impedance sensor for the determination of hydroxyl radicals, based on a graphite electrode modified with electrochemically deposited gold and a self-assembled monolayer of N-acetyl-L-cysteine (NAC). The use of NAC ensures the high selectivity of the sensor, and employing non-Faradaic impedance as a method of recording the analytical signal ensures the limit of detection for OH radicals at the level 0.01 nM with a linearity range of detectable concentrations from 0.08 to 8 nM. The developed sensor has been successfully used to assess the activity of certain antioxidants (ascorbic acid, glutathione, coenzyme Q10) towards OH radicals Текстовый файл AM_Agreement |
| Language: | English |
| Published: |
2024
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| Subjects: | |
| Online Access: | https://doi.org/10.1134/S1061934824700035 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=675854 |
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| 200 | 1 | |a An N-Acetyl-L-Cysteine Impedance Sensor for Assessing Antioxidant Activity against Hydroxyl Radicals |f A. V. Erkovich, E. I. Korotkova, E. V. Dorozhko [et al.] | |
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| 330 | |a The hydroxyl radical is the most aggressive and dangerous product of incomplete oxygen reduction in a body, making its determination and the effect of various antioxidants on the inhibition of OH radicals a pertinent task. We propose an impedance sensor for the determination of hydroxyl radicals, based on a graphite electrode modified with electrochemically deposited gold and a self-assembled monolayer of N-acetyl-L-cysteine (NAC). The use of NAC ensures the high selectivity of the sensor, and employing non-Faradaic impedance as a method of recording the analytical signal ensures the limit of detection for OH radicals at the level 0.01 nM with a linearity range of detectable concentrations from 0.08 to 8 nM. The developed sensor has been successfully used to assess the activity of certain antioxidants (ascorbic acid, glutathione, coenzyme Q10) towards OH radicals | ||
| 336 | |a Текстовый файл | ||
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| 461 | 1 | |t Journal of Analytical Chemistry |c New York |n Springer Science+Business Media LLC. | |
| 463 | 1 | |t Vol. 79, iss. 6 |v P. 663–670 |d 2024 | |
| 610 | 1 | |a электронный ресурс | |
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| 610 | 1 | |a hydroxyl radical | |
| 610 | 1 | |a impedance spectroscopy | |
| 610 | 1 | |a antioxidant activity | |
| 610 | 1 | |a ascorbic acid | |
| 610 | 1 | |a glutathione | |
| 610 | 1 | |a coenzyme Q10 | |
| 701 | 1 | |a Erkovich |b A. V. |c chemical technologist |c engineer of Tomsk Polytechnic University |f 1997- |g Alina Vadimovna |9 23015 | |
| 701 | 1 | |a Korotkova |b E. I. |c chemist |c Professor of Tomsk Polytechnic University, Doctor of chemical science |f 1965- |g Elena Ivanovna |9 15456 | |
| 701 | 1 | |a Dorozhko |b E. V. |c chemist |c Engineer of Tomsk Polytechnic University |f 1979- |g Elena Vladimirovna |9 16175 | |
| 701 | 1 | |a Solomonenko |b A. N. |c Chemical engineer |c Engineer of Tomsk Polytechnic University |f 1995- |g Anna Nikolaevna |9 22606 | |
| 701 | 1 | |a Aseeva |b N. V. |c Chemical engineer |c Engineer of Tomsk Polytechnic University |f 1995- |g Natalya Valerevna |9 22125 | |
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