An N-Acetyl-L-Cysteine Impedance Sensor for Assessing Antioxidant Activity against Hydroxyl Radicals
| Parent link: | Journal of Analytical Chemistry.— .— New York: Springer Science+Business Media LLC. Vol. 79, iss. 6.— 2024.— P. 663–670 |
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| Other Authors: | , , , , |
| Summary: | Title screen The hydroxyl radical is the most aggressive and dangerous product of incomplete oxygen reduction in a body, making its determination and the effect of various antioxidants on the inhibition of OH radicals a pertinent task. We propose an impedance sensor for the determination of hydroxyl radicals, based on a graphite electrode modified with electrochemically deposited gold and a self-assembled monolayer of N-acetyl-L-cysteine (NAC). The use of NAC ensures the high selectivity of the sensor, and employing non-Faradaic impedance as a method of recording the analytical signal ensures the limit of detection for OH radicals at the level 0.01 nM with a linearity range of detectable concentrations from 0.08 to 8 nM. The developed sensor has been successfully used to assess the activity of certain antioxidants (ascorbic acid, glutathione, coenzyme Q10) towards OH radicals Текстовый файл AM_Agreement |
| Published: |
2024
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| Online Access: | https://doi.org/10.1134/S1061934824700035 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=675854 |