Pharmacokinetics of a New Neuroprotector — Indenoquinoxalinone Derivative after Intravenous Administration in Rabbits and Rats; Bulletin of Experimental Biology and Medicine; Vol. 175, iss. 6

Pharmacokinetics of a New Neuroprotector — Indenoquinoxalinone Derivative after Intravenous Administration in Rabbits and Rats; Bulletin of Experimental Biology and Medicine; Vol. 175, iss. 6

Xehetasun bibliografikoak
Parent link:	Bulletin of Experimental Biology and Medicine.— .— New York: Springer Science+Business Media LLC. Vol. 175, iss. 6.— 2023.— P. 770-773
Erakunde egilea:	Томский политехнический университет
Beste egile batzuk:	Yanovskaya E. A. Elena Anatoljevna, Frelikh G. A. Galina Andreevna, Lakeev A. P. Aleksandr Pavlovich, Chernysheva G. A. Galina Anatoljevna, Smolyakova V. I. Vera Ivanovna, Kovrizhina A. R. Anastasia Ruslanovna
Gaia:	Title screen The specific JNK inhibitor and NO donor 11H-indeno[1,2-b]quinoxalin-11-one oxime (IQ-1) demonstrated pronounced neuroprotective properties in an in vivo model of ischemic stroke in rats. The pharmacokinetic behavior of IQ-1 was studied in two animal species (rats, rabbits) after intravenous administration in a dose of 1 mg/kg. IQ-1 concentrations in venous blood plasma were measured by the liquid chromatography—tandem mass spectrometry method. The pharmacokinetics of IQ-1 was adequately described by the two-compartmental model. The calculated C0 for IQ-1 in rabbit and rat plasma were 2239.83±1229.55 and 1552.50±182.23 ng/ml, respectively. Two animal species are characterized by extensive tissue distribution of IQ-1 (Vss exceeded the total body water in rabbits and rats by 3.6 and 5.6 times, respectively) and high clearance values (88-94% of hepatic blood flow) AM_Agreement
Hizkuntza:	ingelesa
Argitaratua:	2023
Gaiak:	электронный ресурс труды учёных ТПУ 11H-indeno[1,2-b]quinoxalin-11-one oxime pharmacokinetics HPLC neuroprotector JNK inhibitor
Sarrera elektronikoa:	https://doi.org/10.1007/s10517-023-05943-7
Formatua:	Baliabide elektronikoa Liburu kapitulua
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=672278

Antzeko izenburuak

The IQ-1S JNK (c-Jun N-Terminal Kinase) Inhibitor Suppresses Premature Aging of OXYS Rat Brain; Neurochemical Journal; Vol. 17, iss. 3
Argitaratua: (2023)

Antihypertensive activity of a new c-Jun N-terminal kinase inhibitor in spontaneously hypertensive rats; Hypertension Research; Vol. 43
Argitaratua: (2020)

Effect of IQ-1 on the Infarct Size and the Parameters of Cardiodynamic Indicators in the Acute Period after Myocardial Ischemia/Reperfusion in Rats; Bulletin of Experimental Biology and Medicine; Vol. 176, iss. 4
Argitaratua: (2024)

Evaluation of Nitric Oxide-Donating Properties of 11H-indeno[1,2-b]quinoxalin-11-one Oxime (IQ-1) by Electron Paramagnetic Resonance Spectroscopy; Molecules; Vol. 29, iss. 16
Argitaratua: (2024)

Cardioprotective Effects of a Selective c-Jun N-terminal Kinase Inhibitor in a Rat Model of Myocardial Infarction; Biomedicines; Vol. 11, iss. 3
Argitaratua: (2023)

Novel c-Jun N-Terminal Kinase (JNK) Inhibitors with an 11H-Indeno[1,2-b]quinoxalin-11-one Scaffold; Molecules; Vol. 26, iss. 18
Argitaratua: (2021)

Synthesis, biological evaluation, and molecular modeling of 11H-indeno[1,2-b]quinoxalin-11-one derivatives and tryptanthrin-6-oxime as c-Jun N-terminal kinase inhibitors; European Journal of Medicinal Chemistry; Vol. 161
Argitaratua: (2018)

Neuroprotective Effects of the Lithium Salt of a Novel JNK Inhibitor in an Animal Model of Cerebral Ischemia-Reperfusion; Biomedicines; Vol. 10, iss. 9
Argitaratua: (2022)

Design, synthesis and biological evaluation of novel O-substituted tryptanthrin oxime derivatives as c-Jun N-terminal kinase inhibitors; Frontiers in Pharmacology; Vol. 13
Argitaratua: (2022)

11H-Indeno[1,2-b]quinoxalin-11-one 2-(4-Ethylbenzylidene)hydrazone; Molbank; Vol. 2021, iss. 4
nork: Kovrizhina A. R. Anastasia Ruslanovna
Argitaratua: (2021)

Development and validation of HPLC-UV method for quantitation of a new antithrombotic drug in rat plasma and its application to pharmacokinetic studies; Journal of Chromatography B; Vol. 1160
Argitaratua: (2020)

Dose proportionality and bioavailability of quinoxaline-based JNK inhibitor after single oral and intravenous administration in rats; Xenobiotica; Vol. 54, iss. 1
Argitaratua: (2024)

Alterations of JNK Signaling Pathway Activity in the Rat Retina: Effects of Age, Age-Related Macular Degeneration-like Pathology, and a JNK Inhibitor (IQ-1S); Cells; Vol. 14, iss. 12
Argitaratua: (2025)

JNK Signaling Pathway Activity Alterations in the Rat Hippocampus: Effect of Age, Alzheimer’s Disease-Like Pathology Development, and the JNK Inhibitor IQ-1S; Biochemistry (Moscow); Vol. 90, iss. 2
Argitaratua: (2025)

Regulation of Blood–Brain Barrier Permeability via JNK Signaling Pathway: Mechanisms and Potential Therapeutic Strategies for Ischemic Stroke, Alzheimer’s Disease and Brain Tumors; Molecules; Vol. 30, iss. 11
Argitaratua: (2025)

Protective Effects of a New C-Jun N-terminal Kinase Inhibitor in the Model of Global Cerebral Ischemia in Rats; Molecules; Vol. 24, iss. 9
Argitaratua: (2019)

Оксим инденохиноксалинона IQ-1 как перспективный агент для разработки лекарственных препаратов; Перспективы развития фундаментальных наук; Т. 2 : Химия
nork: Коврижина А. Р. Анастасия Руслановна
Argitaratua: (2024)

Experimental and Computational Investigation of the Oxime Bond Stereochemistry in c-Jun N-terminal Kinase 3 Inhibitors 11H-Indeno[1,2-b]quinoxalin-11-one Oxime and Tryptanthrin-6-oxime; Pharmaceutics; Vol. 15, iss. 7
Argitaratua: (2023)

c-Jun N-Terminal Kinases and Their Pharmacological Modulation in Ischemic and Reperfusion Brain Injury; Neuroscience and Behavioral Physiology; Vol. 48, iss. 6
Argitaratua: (2019)

Poly(ε-caprolactone) Scaffolds Doped with c-Jun N-terminal Kinase Inhibitors Modulate Phagocyte Activation; ACS Biomaterials Science and Engineering; Vol. 5, iss. 11
Argitaratua: (2019)

Inhibitory effect of IQ-1S, a selective c-Jun N-terminal kinase (JNK) inhibitor, on phenotypical and cytokine-producing characteristics in human macrophages and T-cells; European Journal of Pharmacology; Vol. 878
Argitaratua: (2020)

Laser-synthesized TiN nanoparticles for biomedical applications: Evaluation of safety, biodistribution and pharmacokinetics; Materials Science and Engineering: C; Vol. 120
Argitaratua: (2021)

c-Jun N-Terminal Kinases (JNKs) in Myocardial and Cerebral Ischemia/Reperfusion Injury; Frontiers in Pharmacology; Vol. 9
Argitaratua: (2018)

c-Jun N-Terminal Kinase (JNK) Inhibitor IQ-1S as a Suppressor of Tumor Spheroid Growth; Molecules; Vol. 30, iss. 21
Argitaratua: (2025)

Oximes: Novel Therapeutics with Anticancer and Anti-Inflammatory Potential; Biomolecules; Vol. 11, iss. 6
Argitaratua: (2021)

Novel Tryptanthrin Derivatives with Selectivity as c–Jun N–Terminal Kinase (JNK) 3 Inhibitors; Molecules; Vol. 28, iss. 12
Argitaratua: (2023)

Therapeutic Effects of Tryptanthrin and Tryptanthrin-6-Oxime in Models of Rheumatoid Arthritis; Frontiers in Pharmacology; Vol. 11
Argitaratua: (2020)

Unravelling the speciation of gold(I) fluorinated benzenethiolates using hyphenated HPLC/ICP-AES and HPLC/ESI-MS techniques; Talanta; Vol. 298, Pt. B
Argitaratua: (2026)

Comparative Evaluation of Neuroprotective Activity of Tryptanthrin and Its Oxime in Middle Cerebral Artery Occlusion in Rats; Bulletin of Experimental Biology and Medicine; Vol. 177, iss. 3
Argitaratua: (2024)

The Effect of Tryptanthrin and Its Oxime on the Blood–Brain Barrier Permeability in Rats with Cerebral Infarction; Bulletin of Experimental Biology and Medicine; Vol. 179, iss. 2
Argitaratua: (2025)

Isoxazol-5(2H)-one: a new scaffold for potent human neutrophil elastase (HNE) inhibitors; Journal of Enzyme Inhibition and Medicinal Chemistry; Vol. 32, iss. 1
Argitaratua: (2017)

Влияние плотности посадки кижуча (Oncorhynchus kisutch (Walbaum)) на содержание гормонов стресса и выживаемость потомства; Экология; № 2
nork: Ардашев А. А.
Argitaratua: (2002)

Новгородская служебная Минея на май. XI век. (Путятина Минея): Текст. Исследования. Указатели
Argitaratua: (Ижевск, Удмурдский университет, 2003)

Алгебра и начала анализа: учебник
nork: Башмаков М. И. Марк Иванович
Argitaratua: (Москва, Просвещение, 1993)

Neuroprotective Effects of Tryptanthrin-6-Oxime in a Rat Model of Transient Focal Cerebral Ischemia; Pharmaceuticals; Vol. 16, iss. 8
Argitaratua: (2023)

Determination of Hydrophilic Bioactive Substances in Liquid and Dry Extracts of Sea Buckthorn; Research in “Chemical, Biological & Environmental Sciences” (RCBES-23)
Argitaratua: (2023)

Из "Шах-наме"
nork: Фирдоуси А. Абулькасим
Argitaratua: (Москва, Художественная литература, 1969)

Simultaneous HPLC-UV Determination of Lactic Acid, Glycolic Acid, Glycolide, Lactide and Ethyl Acetate in Monomers for Producing Biodegradable Polymers; Procedia Chemistry; Vol. 10 : Chemistry and Chemical Engineering in XXI century
Argitaratua: (2014)

Кн. 2: Иконы ХI-XIII веков; Русская иконопись
Argitaratua: (1983)

История России. Киевская Русь
nork: Вернадский Г. В. Георгий Владимирович
Argitaratua: (Москва, Леан, 1996)