Pharmacokinetics of a New Neuroprotector — Indenoquinoxalinone Derivative after Intravenous Administration in Rabbits and Rats

Pharmacokinetics of a New Neuroprotector — Indenoquinoxalinone Derivative after Intravenous Administration in Rabbits and Rats

Bibliographic Details
Parent link:Bulletin of Experimental Biology and Medicine.— .— New York: Springer Science+Business Media LLC.
Vol. 175, iss. 6.— 2023.— P. 770-773
Corporate Author: National Research Tomsk Polytechnic University
Other Authors: Yanovskaya E. A. Elena Anatoljevna, Frelikh G. A. Galina Andreevna, Lakeev A. P. Aleksandr Pavlovich, Chernysheva G. A. Galina Anatoljevna, Smolyakova V. I. Vera Ivanovna, Kovrizhina A. R. Anastasia Ruslanovna
Summary:Title screen
The specific JNK inhibitor and NO donor 11H-indeno[1,2-b]quinoxalin-11-one oxime (IQ-1) demonstrated pronounced neuroprotective properties in an in vivo model of ischemic stroke in rats. The pharmacokinetic behavior of IQ-1 was studied in two animal species (rats, rabbits) after intravenous administration in a dose of 1 mg/kg. IQ-1 concentrations in venous blood plasma were measured by the liquid chromatography—tandem mass spectrometry method. The pharmacokinetics of IQ-1 was adequately described by the two-compartmental model. The calculated C0 for IQ-1 in rabbit and rat plasma were 2239.83±1229.55 and 1552.50±182.23 ng/ml, respectively. Two animal species are characterized by extensive tissue distribution of IQ-1 (Vss exceeded the total body water in rabbits and rats by 3.6 and 5.6 times, respectively) and high clearance values (88-94% of hepatic blood flow)
AM_Agreement
Language:English
Published: 2023
Subjects:
электронный ресурс
труды учёных ТПУ
11H-indeno[1,2-b]quinoxalin-11-one oxime
pharmacokinetics
HPLC
neuroprotector
JNK inhibitor
Online Access:https://doi.org/10.1007/s10517-023-05943-7
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=672278

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