Pharmacokinetics of a New Neuroprotector — Indenoquinoxalinone Derivative after Intravenous Administration in Rabbits and Rats; Bulletin of Experimental Biology and Medicine; Vol. 175, iss. 6
| Parent link: | Bulletin of Experimental Biology and Medicine.— .— New York: Springer Science+Business Media LLC. Vol. 175, iss. 6.— 2023.— P. 770-773 |
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| Diğer Yazarlar: | , , , , , |
| Özet: | Title screen The specific JNK inhibitor and NO donor 11H-indeno[1,2-b]quinoxalin-11-one oxime (IQ-1) demonstrated pronounced neuroprotective properties in an in vivo model of ischemic stroke in rats. The pharmacokinetic behavior of IQ-1 was studied in two animal species (rats, rabbits) after intravenous administration in a dose of 1 mg/kg. IQ-1 concentrations in venous blood plasma were measured by the liquid chromatography—tandem mass spectrometry method. The pharmacokinetics of IQ-1 was adequately described by the two-compartmental model. The calculated C0 for IQ-1 in rabbit and rat plasma were 2239.83±1229.55 and 1552.50±182.23 ng/ml, respectively. Two animal species are characterized by extensive tissue distribution of IQ-1 (Vss exceeded the total body water in rabbits and rats by 3.6 and 5.6 times, respectively) and high clearance values (88-94% of hepatic blood flow) AM_Agreement |
| Dil: | İngilizce |
| Baskı/Yayın Bilgisi: |
2023
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| Online Erişim: | https://doi.org/10.1007/s10517-023-05943-7 |
| Materyal Türü: | Elektronik Kitap Bölümü |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=672278 |