Pharmacokinetics of a New Neuroprotector — Indenoquinoxalinone Derivative after Intravenous Administration in Rabbits and Rats
| Parent link: | Bulletin of Experimental Biology and Medicine.— .— New York: Springer Science+Business Media LLC. Vol. 175, iss. 6.— 2023.— P. 770-773 |
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| Autor Corporativo: | |
| Outros autores: | , , , , , |
| Summary: | Title screen The specific JNK inhibitor and NO donor 11H-indeno[1,2-b]quinoxalin-11-one oxime (IQ-1) demonstrated pronounced neuroprotective properties in an in vivo model of ischemic stroke in rats. The pharmacokinetic behavior of IQ-1 was studied in two animal species (rats, rabbits) after intravenous administration in a dose of 1 mg/kg. IQ-1 concentrations in venous blood plasma were measured by the liquid chromatography—tandem mass spectrometry method. The pharmacokinetics of IQ-1 was adequately described by the two-compartmental model. The calculated C0 for IQ-1 in rabbit and rat plasma were 2239.83±1229.55 and 1552.50±182.23 ng/ml, respectively. Two animal species are characterized by extensive tissue distribution of IQ-1 (Vss exceeded the total body water in rabbits and rats by 3.6 and 5.6 times, respectively) and high clearance values (88-94% of hepatic blood flow) AM_Agreement |
| Idioma: | inglés |
| Publicado: |
2023
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| Subjects: | |
| Acceso en liña: | https://doi.org/10.1007/s10517-023-05943-7 |
| Formato: | Electrónico Capítulo de libro |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=672278 |
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| 200 | 1 | |a Pharmacokinetics of a New Neuroprotector — Indenoquinoxalinone Derivative after Intravenous Administration in Rabbits and Rats |f E. A. Yanovskaya, G. A. Frelikh, A. P. Lakeev [et al.] | |
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| 300 | |a Title screen | ||
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| 330 | |a The specific JNK inhibitor and NO donor 11H-indeno[1,2-b]quinoxalin-11-one oxime (IQ-1) demonstrated pronounced neuroprotective properties in an in vivo model of ischemic stroke in rats. The pharmacokinetic behavior of IQ-1 was studied in two animal species (rats, rabbits) after intravenous administration in a dose of 1 mg/kg. IQ-1 concentrations in venous blood plasma were measured by the liquid chromatography—tandem mass spectrometry method. The pharmacokinetics of IQ-1 was adequately described by the two-compartmental model. The calculated C0 for IQ-1 in rabbit and rat plasma were 2239.83±1229.55 and 1552.50±182.23 ng/ml, respectively. Two animal species are characterized by extensive tissue distribution of IQ-1 (Vss exceeded the total body water in rabbits and rats by 3.6 and 5.6 times, respectively) and high clearance values (88-94% of hepatic blood flow) | ||
| 371 | 0 | |a AM_Agreement | |
| 461 | 1 | |t Bulletin of Experimental Biology and Medicine |c New York |n Springer Science+Business Media LLC. | |
| 463 | 1 | |t Vol. 175, iss. 6 |v P. 770-773 |d 2023 | |
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a 11H-indeno[1,2-b]quinoxalin-11-one oxime | |
| 610 | 1 | |a pharmacokinetics | |
| 610 | 1 | |a HPLC | |
| 610 | 1 | |a neuroprotector | |
| 610 | 1 | |a JNK inhibitor | |
| 701 | 1 | |a Yanovskaya |b E. A. |g Elena Anatoljevna | |
| 701 | 1 | |a Frelikh |b G. A. |g Galina Andreevna | |
| 701 | 1 | |a Lakeev |b A. P. |g Aleksandr Pavlovich | |
| 701 | 1 | |a Chernysheva |b G. A. |g Galina Anatoljevna | |
| 701 | 1 | |a Smolyakova |b V. I. |g Vera Ivanovna | |
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