Periodical amphiphilic surface with chemical patterning for micelles immobilization and analysis
| Parent link: | Applied Surface Science Vol. 586.— 2022.— [152833, 10 p.] |
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| Համատեղ հեղինակ: | |
| Այլ հեղինակներ: | , , , , , , , , , , |
| Ամփոփում: | Title screen We present a strategy to produce periodically patterned surface with the controlled hydrophilic and hydrophobic nanoareas. The developed approach comprises colloid lithography using vapor-annealed polystyrene (PS) microspheres mask and two-step electrochemical surface grafting. The grafting was performed using the diazonium surface chemistry before and after colloid mask removal in order to introduce hydrophilic Ph-COOH and hydrophobic Ph-C8F17 moieties. Grafted chemical moities were covalently attached to the surface. The procedure results in creation of a surface with nanoprecisely located periodical hydrophobic and hydrophilic areas, with different sizes and geometry, determined by vapor annealing of PS microspheres. The created amphiphilic surface shows good biorepelency towards bovine serum albumin (BSA) and a high affinity towards amphiphilic micelles. Variation of surface nanoarchitecture elucidates the optimal surface chemistry for immobilization and surface entrapping of drug-loaded micelles. The formation of additional interface between amphilic surface and micelles was proved by dramatic decrease of the contact angle. According to Fourier-transform infrared spectroscopy (FTIR) results, created amphiphilic surfaces can capture drug-loaded micelles even in the presence of BSA biomatrix. Described procedure represents a versatile and scalable method for the creation of stable amphiphilic coating and its potential application in qualitative analysis and identification of micelles. Режим доступа: по договору с организацией-держателем ресурса |
| Լեզու: | անգլերեն |
| Հրապարակվել է: |
2022
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| Խորագրեր: | |
| Առցանց հասանելիություն: | https://doi.org/10.1016/j.apsusc.2022.152833 |
| Ձևաչափ: | Էլեկտրոնային Գրքի գլուխ |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=668894 |