Metal-Free Synthesis of Heteroaryl Amines or Their Hydrochlorides via an External-Base-Free and Solvent-Free C–N Coupling Protocol; The Journal of Organic Chemistry; Vol. 86, iss. 21

Metal-Free Synthesis of Heteroaryl Amines or Their Hydrochlorides via an External-Base-Free and Solvent-Free C–N Coupling Protocol; The Journal of Organic Chemistry; Vol. 86, iss. 21

Bibliographic Details
Parent link:The Journal of Organic Chemistry
Vol. 86, iss. 21.— 2021.— [P. 14627–14639]
Corporate Author: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
Other Authors: Guang-Gao Fan, Bo-Wen Jiang, Wei Sang, Hua Cheng, Rui Zhang, Bao-Yi Yu, Ye Yuan, Cheng Chen, Verpoort F. V. K. Frensis Valter Kornelius
Summary:Title screen
Herein, a metal-free and solvent-free protocol was developed for the C−N coupling of heteroaryl halides and amines, which afforded numerous heteroaryl amines or their hydrochlorides without any external base. Further investigations elucidated that the basicity of amines and specific interactions derived from the X-ray crystallography analysis of 3j′·HCl played pivotal roles in the reactions. Moreover, this protocol was scalable to gram scales and applicable to drug molecules, which demonstrated its practical value for further applications.
Режим доступа: по договору с организацией-держателем ресурса
Language:English
Published: 2021
Subjects:
электронный ресурс
труды учёных ТПУ
Online Access:https://doi.org/10.1021/acs.joc.1c01467
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=667895

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