Metal-Free Synthesis of Heteroaryl Amines or Their Hydrochlorides via an External-Base-Free and Solvent-Free C–N Coupling Protocol

Detalles Bibliográficos
Parent link:	The Journal of Organic Chemistry Vol. 86, iss. 21.— 2021.— [P. 14627–14639]
Autor Corporativo:	Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
Otros Autores:	Guang-Gao Fan, Bo-Wen Jiang, Wei Sang, Hua Cheng, Rui Zhang, Bao-Yi Yu, Ye Yuan, Cheng Chen, Verpoort F. V. K. Frensis Valter Kornelius
Sumario:	Title screen Herein, a metal-free and solvent-free protocol was developed for the C−N coupling of heteroaryl halides and amines, which afforded numerous heteroaryl amines or their hydrochlorides without any external base. Further investigations elucidated that the basicity of amines and specific interactions derived from the X-ray crystallography analysis of 3j′·HCl played pivotal roles in the reactions. Moreover, this protocol was scalable to gram scales and applicable to drug molecules, which demonstrated its practical value for further applications. Режим доступа: по договору с организацией-держателем ресурса
Publicado:	2021
Materias:	электронный ресурс труды учёных ТПУ
Acceso en línea:	https://doi.org/10.1021/acs.joc.1c01467
Formato:	Electrónico Capítulo de libro
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=667895

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