Metal-Free Synthesis of Heteroaryl Amines or Their Hydrochlorides via an External-Base-Free and Solvent-Free C–N Coupling Protocol; The Journal of Organic Chemistry; Vol. 86, iss. 21
| Parent link: | The Journal of Organic Chemistry Vol. 86, iss. 21.— 2021.— [P. 14627–14639] |
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| Autor corporatiu: | |
| Altres autors: | , , , , , , , , |
| Sumari: | Title screen Herein, a metal-free and solvent-free protocol was developed for the C−N coupling of heteroaryl halides and amines, which afforded numerous heteroaryl amines or their hydrochlorides without any external base. Further investigations elucidated that the basicity of amines and specific interactions derived from the X-ray crystallography analysis of 3j′·HCl played pivotal roles in the reactions. Moreover, this protocol was scalable to gram scales and applicable to drug molecules, which demonstrated its practical value for further applications. Режим доступа: по договору с организацией-держателем ресурса |
| Idioma: | anglès |
| Publicat: |
2021
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| Matèries: | |
| Accés en línia: | https://doi.org/10.1021/acs.joc.1c01467 |
| Format: | Electrònic Capítol de llibre |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=667895 |
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| 200 | 1 | |a Metal-Free Synthesis of Heteroaryl Amines or Their Hydrochlorides via an External-Base-Free and Solvent-Free C–N Coupling Protocol |f Guang-Gao Fan, Bo-Wen Jiang, Wei Sang [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 17 tit.] | ||
| 330 | |a Herein, a metal-free and solvent-free protocol was developed for the C−N coupling of heteroaryl halides and amines, which afforded numerous heteroaryl amines or their hydrochlorides without any external base. Further investigations elucidated that the basicity of amines and specific interactions derived from the X-ray crystallography analysis of 3j′·HCl played pivotal roles in the reactions. Moreover, this protocol was scalable to gram scales and applicable to drug molecules, which demonstrated its practical value for further applications. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t The Journal of Organic Chemistry | ||
| 463 | |t Vol. 86, iss. 21 |v [P. 14627–14639] |d 2021 | ||
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| 701 | 0 | |a Wei Sang | |
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| 701 | 0 | |a Ye Yuan | |
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