Fabrication and characterization of a magnetic biocomposite of magnetite nanoparticles and reduced graphene oxide for biomedical applications
| Parent link: | Nano-Structures and Nano-Objects Vol. 29.— 2021.— [100843, 15] |
|---|---|
| Corporate Author: | |
| Other Authors: | , , , , , , , , , , , |
| Summary: | Title screen Functionalization of magnetite (Fe3O4) nanoparticles with reduced graphene oxide (rGO) with the preserved magnetic properties of the former presents great potential for applying the Fe3O4/rGO biocomposite in various biomedical applications, such as magnetic resonance imaging, as a therapeutic component in initiating tumour cell death in magnetic and photon ablation therapy, and as an effective carrier for drug delivery. In this study, magnetite nanoparticles (MNPs) with a high saturation magnetization were synthesized by co-precipitation under various conditions, followed by covalent functionalization with citric acid (CA) and subsequent attachment to rGO sheets by physical adsorption. Extensive characterization revealed increasing phase purity with a subsequent decrease in the crystallite size and average size of the MNPs synthesized in an inert atmosphere compared to ambient conditions. Meanwhile, further functionalization of the MNPs with CA by covalent binding does not affect the MNP structure and size, but decreases their agglomeration. To study the magnetic properties of the MNPs and the Fe3O4/rGO composite, magnetization curves were obtained with a vibrating sample magnetometer at a pulsed magnetic field of up to 6.5 kOe. The largest values of saturation magnetization are revealed for the samples synthesized without the addition of CA in an inert atmosphere ( emu/g). The addition of CA to the synthesized MNPs and Fe3O4/rGO composites reduced agglomeration, with values in the range from 64.10 to 60.97 emu/g. In vitro biological experiments revealed the MNP concentrations that did not cause any toxic effects on cells for use as magnetic fillers to investigate the strain-mediated effects of hybrid polymer composites on cellular behaviour due to external magnetic field exposure in the next stages of research. Режим доступа: по договору с организацией-держателем ресурса |
| Published: |
2021
|
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.nanoso.2022.100843 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=667756 |