Transition-Metal-Free Base-Controlled C−N Coupling Reactions: Selective Mono Versus Diarylation of Primary Amines with 2-Chlorobenzimidazoles; Advanced Synthesis and Catalysis; Vol. 363, iss. 5
| Parent link: | Advanced Synthesis and Catalysis Vol. 363, iss. 5.— 2021.— [P. 1408-1416] |
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| Awdur Corfforaethol: | |
| Awduron Eraill: | , , , , , , , , |
| Crynodeb: | Title screen Herein, a base-controlled protocol was developed for the C−N coupling of primary amines and 2-chlorobenzimidazoles, affording a handful of secondary or tertiary amines in a selective fashion. Moreover, this protocol was realized under transition-metal-free conditions, and the variation of the base from iPr2NH to LiOtBu completely switched the selectivity from monoarylation to diarylation. Further investigations elucidated that the variety, intrinsic basicity and amount of the utilized bases considerably affected these reactions. |
| Iaith: | Saesneg |
| Cyhoeddwyd: |
2021
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| Pynciau: | |
| Mynediad Ar-lein: | https://doi.org/10.1002/adsc.202001365 |
| Fformat: | Electronig Pennod Llyfr |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=667545 |
| Crynodeb: | Title screen Herein, a base-controlled protocol was developed for the C−N coupling of primary amines and 2-chlorobenzimidazoles, affording a handful of secondary or tertiary amines in a selective fashion. Moreover, this protocol was realized under transition-metal-free conditions, and the variation of the base from iPr2NH to LiOtBu completely switched the selectivity from monoarylation to diarylation. Further investigations elucidated that the variety, intrinsic basicity and amount of the utilized bases considerably affected these reactions. |
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| DOI: | 10.1002/adsc.202001365 |