Transition-Metal-Free Base-Controlled C−N Coupling Reactions: Selective Mono Versus Diarylation of Primary Amines with 2-Chlorobenzimidazoles

Bibliographic Details
Parent link:	Advanced Synthesis and Catalysis Vol. 363, iss. 5.— 2021.— [P. 1408-1416]
Corporate Author:	Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
Other Authors:	Wei Sang, Yan-Yan Gong, Hua Cheng, Rui Zhang, Ye Yuan, Guang-Gao Fan, Zhi-Qin Wang, Cheng Chen, Verpoort F. V. K. Frensis Valter Kornelius
Summary:	Title screen Herein, a base-controlled protocol was developed for the C−N coupling of primary amines and 2-chlorobenzimidazoles, affording a handful of secondary or tertiary amines in a selective fashion. Moreover, this protocol was realized under transition-metal-free conditions, and the variation of the base from iPr2NH to LiOtBu completely switched the selectivity from monoarylation to diarylation. Further investigations elucidated that the variety, intrinsic basicity and amount of the utilized bases considerably affected these reactions.
Published:	2021
Subjects:	электронный ресурс труды учёных ТПУ transition-metal-free base-controlled CN coupling diarylation monoarylation 2-aminobenzimida-zoles переходные металлы амины
Online Access:	https://doi.org/10.1002/adsc.202001365
Format:	Electronic Book Chapter
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=667545

Internet

https://doi.org/10.1002/adsc.202001365