11H-Indeno[1,2-b]quinoxalin-11-one 2-(4-Ethylbenzylidene)hydrazone
| Parent link: | Molbank Vol. 2021, iss. 4.— 2021.— [M1299, 7 p.] |
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| Other Authors: | , |
| Summary: | Title screen 11H-Indeno[1,2-b]quinoxaline derivatives present an important type of nitrogen-containing heterocyclic compound that are useful intermediate products in organic synthesis and have potential pharmaceutical applications. A new 11H-indeno[1,2-b]quinoxalin-11-one-2-(4-ethylbenzylidene)hydrazone (compound 3) was synthesized. Compound 3 is the first example of an azine derivative based on the 11H-indeno[1,2-b]quinoxaline system. The Z,E-isomerism of compound 3 was investigated by DFT calculations. Bioavailability was evaluated in silico using ADME predictions. According to the ADME results, compound 3 is potentially highly bioavailable and has potential to be used for the treatment of neuroinflammation and ischemia–reperfusion injury. |
| Language: | English |
| Published: |
2021
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| Online Access: | https://doi.org/10.3390/M1299 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=666275 |