2-(2-(Fluorosulfonyloxy)phenyl)benzoxazole; Molbank; Vol. 2021, iss. 3

2-(2-(Fluorosulfonyloxy)phenyl)benzoxazole; Molbank; Vol. 2021, iss. 3

Bibliographic Details
Parent link:Molbank
Vol. 2021, iss. 3.— 2021.— [M1242, 5 p.]
Main Author: Danilenko N. V. Nadezhda Viktorovna
Corporate Authors: Национальный исследовательский Томский политехнический университет Инженерная школа ядерных технологий Лаборатория плазменных гибридных систем, Национальный исследовательский Томский политехнический университет Инженерная школа новых производственных технологий Научно-образовательный центр Н. М. Кижнера
Other Authors: Shmalyuk V. I. Vladimir Igorevich, Khlebnikov A. I. Andrey Ivanovich
Summary:Title screen
The fluorosulfate derivatives of benzoxazole attract attention since benzoxazole-based compounds have a wide range of biological activities, and the ability of the -SO2F group to react with various functional groups makes it possible to synthesize various new derivatives. The new 2-(2-(fluorosulfonyloxy)phenyl)benzoxazole (2) has been synthesized by the SuFEx click reaction in a two-chamber reactor. Compound 2 is the first example of a benzoxazole derivative with a fluorosulfate-containing substituent at position two of the benzoxazole heterocycle. The anti-cancer potency of 2 was evaluated in silico using molecular docking. The docking results suggest that title compound 2 is of great interest for further studies as a possible anaplastic lymphoma kinase inhibitor.
Language:English
Published: 2021
Subjects:
электронный ресурс
труды учёных ТПУ
benzoxazole
SuFEx
molecular docking
бензоксазолы
молекулярная стыковка
биологическая активность
противораковая активность
Online Access:https://doi.org/10.3390/M1242
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=665346

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