2-(2-(Fluorosulfonyloxy)phenyl)benzoxazole

2-(2-(Fluorosulfonyloxy)phenyl)benzoxazole

Bibliographic Details
Parent link:	Molbank Vol. 2021, iss. 3.— 2021.— [M1242, 5 p.]
Main Author:	Danilenko N. V. Nadezhda Viktorovna
Corporate Authors:	Национальный исследовательский Томский политехнический университет Инженерная школа ядерных технологий Лаборатория плазменных гибридных систем, Национальный исследовательский Томский политехнический университет Инженерная школа новых производственных технологий Научно-образовательный центр Н. М. Кижнера
Other Authors:	Shmalyuk V. I. Vladimir Igorevich, Khlebnikov A. I. Andrey Ivanovich
Summary:	Title screen The fluorosulfate derivatives of benzoxazole attract attention since benzoxazole-based compounds have a wide range of biological activities, and the ability of the -SO2F group to react with various functional groups makes it possible to synthesize various new derivatives. The new 2-(2-(fluorosulfonyloxy)phenyl)benzoxazole (2) has been synthesized by the SuFEx click reaction in a two-chamber reactor. Compound 2 is the first example of a benzoxazole derivative with a fluorosulfate-containing substituent at position two of the benzoxazole heterocycle. The anti-cancer potency of 2 was evaluated in silico using molecular docking. The docking results suggest that title compound 2 is of great interest for further studies as a possible anaplastic lymphoma kinase inhibitor.
Published:	2021
Subjects:	электронный ресурс труды учёных ТПУ benzoxazole SuFEx molecular docking бензоксазолы молекулярная стыковка биологическая активность противораковая активность
Online Access:	https://doi.org/10.3390/M1242
Format:	Electronic Book Chapter
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=665346

Internet

https://doi.org/10.3390/M1242