2-(2-(Fluorosulfonyloxy)phenyl)benzoxazole
| Parent link: | Molbank Vol. 2021, iss. 3.— 2021.— [M1242, 5 p.] |
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| المؤلف الرئيسي: | |
| مؤلفون مشاركون: | , |
| مؤلفون آخرون: | , |
| الملخص: | Title screen The fluorosulfate derivatives of benzoxazole attract attention since benzoxazole-based compounds have a wide range of biological activities, and the ability of the -SO2F group to react with various functional groups makes it possible to synthesize various new derivatives. The new 2-(2-(fluorosulfonyloxy)phenyl)benzoxazole (2) has been synthesized by the SuFEx click reaction in a two-chamber reactor. Compound 2 is the first example of a benzoxazole derivative with a fluorosulfate-containing substituent at position two of the benzoxazole heterocycle. The anti-cancer potency of 2 was evaluated in silico using molecular docking. The docking results suggest that title compound 2 is of great interest for further studies as a possible anaplastic lymphoma kinase inhibitor. |
| اللغة: | الإنجليزية |
| منشور في: |
2021
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://doi.org/10.3390/M1242 |
| التنسيق: | الكتروني فصل الكتاب |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=665346 |
MARC
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| 200 | 1 | |a 2-(2-(Fluorosulfonyloxy)phenyl)benzoxazole |f N. V. Danilenko, V. I. Shmalyuk, A. I. Khlebnikov | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 11 tit.] | ||
| 330 | |a The fluorosulfate derivatives of benzoxazole attract attention since benzoxazole-based compounds have a wide range of biological activities, and the ability of the -SO2F group to react with various functional groups makes it possible to synthesize various new derivatives. The new 2-(2-(fluorosulfonyloxy)phenyl)benzoxazole (2) has been synthesized by the SuFEx click reaction in a two-chamber reactor. Compound 2 is the first example of a benzoxazole derivative with a fluorosulfate-containing substituent at position two of the benzoxazole heterocycle. The anti-cancer potency of 2 was evaluated in silico using molecular docking. The docking results suggest that title compound 2 is of great interest for further studies as a possible anaplastic lymphoma kinase inhibitor. | ||
| 461 | |t Molbank | ||
| 463 | |t Vol. 2021, iss. 3 |v [M1242, 5 p.] |d 2021 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a benzoxazole | |
| 610 | 1 | |a SuFEx | |
| 610 | 1 | |a molecular docking | |
| 610 | 1 | |a бензоксазолы | |
| 610 | 1 | |a молекулярная стыковка | |
| 610 | 1 | |a биологическая активность | |
| 610 | 1 | |a противораковая активность | |
| 700 | 1 | |a Danilenko |b N. V. |c chemical engineer |c Research Engineer, Tomsk Polytechnic University |f 1992- |g Nadezhda Viktorovna |3 (RuTPU)RU\TPU\pers\37547 |9 20416 | |
| 701 | 1 | |a Shmalyuk |b V. I. |g Vladimir Igorevich | |
| 701 | 1 | |a Khlebnikov |b A. I. |c Chemist |c Professor of Tomsk Polytechnic University |f 1963- |g Andrey Ivanovich |3 (RuTPU)RU\TPU\pers\33927 |9 17500 | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Инженерная школа ядерных технологий |b Лаборатория плазменных гибридных систем |3 (RuTPU)RU\TPU\col\23381 |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Инженерная школа новых производственных технологий |b Научно-образовательный центр Н. М. Кижнера |3 (RuTPU)RU\TPU\col\23556 |
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| 856 | 4 | |u https://doi.org/10.3390/M1242 | |
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