Stereoselective synthesis of unnatural a-amino acid derivatives through photoredox catalysis
| Parent link: | Chemical Science Vol. 12, iss. 15.— 2021.— [5430, 8 p.] |
|---|---|
| Autor corporatiu: | |
| Altres autors: | , , , , , , , , , |
| Sumari: | Title screen A protocol for stereoselective C-radical addition to a chiral glyoxylate-derived N-sulfinyl imine was developed through visible light-promoted photoredox catalysis, providing a convenient method for the synthesis of unnatural a-amino acids. The developed protocol allows the use of ubiquitous carboxylic acids as radical precursors without prior derivatization. The protocol utilizes near-stoichiometric amounts of the imine and the acid radical precursor in combination with a catalytic amount of an organic acridinium-based photocatalyst. Alternative mechanisms for the developed transformation are discussed and corroborated by experimental and computational studies. |
| Idioma: | anglès |
| Publicat: |
2021
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| Matèries: | |
| Accés en línia: | https://doi.org/10.1039/D1SC00658D |
| Format: | Electrònic Capítol de llibre |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664951 |
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| 200 | 1 | |a Stereoselective synthesis of unnatural a-amino acid derivatives through photoredox catalysis |f A. I. Shatsky, A. Axelsson, E. V. Stepanova [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 26 tit.] | ||
| 330 | |a A protocol for stereoselective C-radical addition to a chiral glyoxylate-derived N-sulfinyl imine was developed through visible light-promoted photoredox catalysis, providing a convenient method for the synthesis of unnatural a-amino acids. The developed protocol allows the use of ubiquitous carboxylic acids as radical precursors without prior derivatization. The protocol utilizes near-stoichiometric amounts of the imine and the acid radical precursor in combination with a catalytic amount of an organic acridinium-based photocatalyst. Alternative mechanisms for the developed transformation are discussed and corroborated by experimental and computational studies. | ||
| 461 | |t Chemical Science | ||
| 463 | |t Vol. 12, iss. 15 |v [5430, 8 p.] |d 2021 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 701 | 1 | |a Shatsky |b A. I. |c chemist |c Senior Researcher of Tomsk Polytechnic University |f 1989- |g Andrey Ivanovich |3 (RuTPU)RU\TPU\pers\47139 | |
| 701 | 1 | |a Axelsson |b A. |g Anton | |
| 701 | 1 | |a Stepanova |b E. V. |c chemist |c engineer of Tomsk Polytechnic University |f 1978- |g Elena Vladimirovna |3 (RuTPU)RU\TPU\pers\34245 | |
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