Stereoselective synthesis of unnatural a-amino acid derivatives through photoredox catalysis
| Parent link: | Chemical Science Vol. 12, iss. 15.— 2021.— [5430, 8 p.] |
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| Körperschaft: | |
| Weitere Verfasser: | , , , , , , , , , |
| Zusammenfassung: | Title screen A protocol for stereoselective C-radical addition to a chiral glyoxylate-derived N-sulfinyl imine was developed through visible light-promoted photoredox catalysis, providing a convenient method for the synthesis of unnatural a-amino acids. The developed protocol allows the use of ubiquitous carboxylic acids as radical precursors without prior derivatization. The protocol utilizes near-stoichiometric amounts of the imine and the acid radical precursor in combination with a catalytic amount of an organic acridinium-based photocatalyst. Alternative mechanisms for the developed transformation are discussed and corroborated by experimental and computational studies. |
| Veröffentlicht: |
2021
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| Schlagworte: | |
| Online-Zugang: | https://doi.org/10.1039/D1SC00658D |
| Format: | Elektronisch Buchkapitel |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664951 |