Radiolabeled Complex of Antimicrobial Peptides UBI29-41 and UBI18-35 Labeled with 99mTc for Differential Diagnosis of Bone Infection of the Limbs; Bulletin of Experimental Biology and Medicine; Vol. 170, iss. 4
| Parent link: | Bulletin of Experimental Biology and Medicine Vol. 170, iss. 4.— 2021.— [P. 415-419] |
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| Korporace: | , |
| Další autoři: | , , , , , , , , , , , , , |
| Shrnutí: | Title screen We studied an original radiolabeled complex of antimicrobial peptides UBI29-41 and UBI18-35, ubiquicidin derivatives, for distinguishing between bacterial and aseptic inflammation. For radiolabeling of the peptides with technetium-99m, a bifunctional chelating agent succinimide-1-yl 6-(bis(pyridin-2-ylmethyl)amino)hexanoate was used. The obtained complexes 99mТс-DPAH-UBI29-41 and 99mТс-DPAH-UBI18-35 had radiolabeling yield >80% and radiochemical purity >96%. Accumulation of the complexes in the focus of bacterial inflammation in bone structures and the absence of this complex in the site of aseptic inflammation was confirmed in a rat model of traumatic osteomyelitis by single-photon emission computed tomography. Режим доступа: по договору с организацией-держателем ресурса |
| Jazyk: | angličtina |
| Vydáno: |
2021
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| Témata: | |
| On-line přístup: | https://doi.org/10.1007/s10517-021-05078-7 |
| Médium: | Elektronický zdroj Kapitola |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664885 |
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| 200 | 1 | |a Radiolabeled Complex of Antimicrobial Peptides UBI29-41 and UBI18-35 Labeled with 99mTc for Differential Diagnosis of Bone Infection of the Limbs |f V. D. Zavadovskaya, M. S. Larkina, E. S. Stasyuk (Stasiuk) [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 12 tit.] | ||
| 330 | |a We studied an original radiolabeled complex of antimicrobial peptides UBI29-41 and UBI18-35, ubiquicidin derivatives, for distinguishing between bacterial and aseptic inflammation. For radiolabeling of the peptides with technetium-99m, a bifunctional chelating agent succinimide-1-yl 6-(bis(pyridin-2-ylmethyl)amino)hexanoate was used. The obtained complexes 99mТс-DPAH-UBI29-41 and 99mТс-DPAH-UBI18-35 had radiolabeling yield >80% and radiochemical purity >96%. Accumulation of the complexes in the focus of bacterial inflammation in bone structures and the absence of this complex in the site of aseptic inflammation was confirmed in a rat model of traumatic osteomyelitis by single-photon emission computed tomography. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Bulletin of Experimental Biology and Medicine | ||
| 463 | |t Vol. 170, iss. 4 |v [P. 415-419] |d 2021 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a ubiquicidin | |
| 610 | 1 | |a technetium-99m | |
| 610 | 1 | |a osteomyelitis | |
| 610 | 1 | |a SPECT | |
| 701 | 1 | |a Zavadovskaya |b V. D. |g Vera Dmitrievna | |
| 701 | 1 | |a Larkina |b M. S. |c pharmacist |c Researcher of the Tomsk Polytechnic University, Candidate of Pharmaceutical Sciences |f 1984- |g Mariya Sergeevna |3 (RuTPU)RU\TPU\pers\46781 | |
| 701 | 1 | |a Stasyuk (Stasiuk) |b E. S. |c Specialist in the field of nuclear power engineering |c Researcher of Tomsk Polytechnic University, Candidate of technical sciences |f 1978- |g Elena Sergeyevna |3 (RuTPU)RU\TPU\pers\32656 |9 16555 | |
| 701 | 1 | |a Zorkaltsev |b M. A. |g Maksim Aleksandrovich | |
| 701 | 1 | |a Udodov |b V. D. |g Vladimir Dmitrievich | |
| 701 | 1 | |a Ivanov |b V. V. |g Vladimir Vladimirovich | |
| 701 | 1 | |a Shevtsova |b N. M. |g Nataljya Mikhaylovna | |
| 701 | 1 | |a Rogov |b A. S. |c Radiochemist |c Engineer of Tomsk Polytechnic University |f 1986- |g Alexander Sergeyevich |3 (RuTPU)RU\TPU\pers\32658 | |
| 701 | 1 | |a Lushchik |b A. Ya. |g Aleksandr Yakovlevich | |
| 701 | 1 | |a Yantsevich |b A. V. |g Aleksey Viktorovich | |
| 701 | 1 | |a Belousov |b M. V. |c chemist |c Professor of Tomsk Polytechnic University, Doctor of Pharmaceutical Sciences |f 1963- |g Mikhail Valerievich |3 (RuTPU)RU\TPU\pers\45418 | |
| 701 | 1 | |a Baykov |b A. N. |g Aleksandr Nikolaevich | |
| 701 | 1 | |a Skuridin |b V. S. |c Physicist, Specialist in the field of nuclear power engineering |c Professor of Tomsk Polytechnic University, Doctor of technical sciences |f 1946- |g Viktor Sergeyevich |3 (RuTPU)RU\TPU\pers\32655 | |
| 701 | 1 | |a Pershina |b A. G. |c biologist |c Associate Professor of Tomsk Polytechnic University, Candidate of biological sciences |f 1981- |g Aleksandra Gennadievna |3 (RuTPU)RU\TPU\pers\32466 |9 16414 | |
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