Radiolabeled Complex of Antimicrobial Peptides UBI29-41 and UBI18-35 Labeled with 99mTc for Differential Diagnosis of Bone Infection of the Limbs

Radiolabeled Complex of Antimicrobial Peptides UBI29-41 and UBI18-35 Labeled with 99mTc for Differential Diagnosis of Bone Infection of the Limbs

Bibliographic Details
Parent link:	Bulletin of Experimental Biology and Medicine Vol. 170, iss. 4.— 2021.— [P. 415-419]
Corporate Authors:	Национальный исследовательский Томский политехнический университет (ТПУ) Физико-технический институт (ФТИ) Лаборатория радиационного контроля № 31 (Лаборатория РК № 31), Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий Научно-исследовательский центр "Онкотераностика"
Other Authors:	Zavadovskaya V. D. Vera Dmitrievna, Larkina M. S. Mariya Sergeevna, Stasyuk (Stasiuk) E. S. Elena Sergeyevna, Zorkaltsev M. A. Maksim Aleksandrovich, Udodov V. D. Vladimir Dmitrievich, Ivanov V. V. Vladimir Vladimirovich, Shevtsova N. M. Nataljya Mikhaylovna, Rogov A. S. Alexander Sergeyevich, Lushchik A. Ya. Aleksandr Yakovlevich, Yantsevich A. V. Aleksey Viktorovich, Belousov M. V. Mikhail Valerievich, Baykov A. N. Aleksandr Nikolaevich, Skuridin V. S. Viktor Sergeyevich, Pershina A. G. Aleksandra Gennadievna
Summary:	Title screen We studied an original radiolabeled complex of antimicrobial peptides UBI29-41 and UBI18-35, ubiquicidin derivatives, for distinguishing between bacterial and aseptic inflammation. For radiolabeling of the peptides with technetium-99m, a bifunctional chelating agent succinimide-1-yl 6-(bis(pyridin-2-ylmethyl)amino)hexanoate was used. The obtained complexes 99mТс-DPAH-UBI29-41 and 99mТс-DPAH-UBI18-35 had radiolabeling yield >80% and radiochemical purity >96%. Accumulation of the complexes in the focus of bacterial inflammation in bone structures and the absence of this complex in the site of aseptic inflammation was confirmed in a rat model of traumatic osteomyelitis by single-photon emission computed tomography. Режим доступа: по договору с организацией-держателем ресурса
Published:	2021
Subjects:	электронный ресурс труды учёных ТПУ ubiquicidin technetium-99m osteomyelitis SPECT
Online Access:	https://doi.org/10.1007/s10517-021-05078-7
Format:	Electronic Book Chapter
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664885

Internet

https://doi.org/10.1007/s10517-021-05078-7