Radiolabeled Complex of Antimicrobial Peptides UBI29-41 and UBI18-35 Labeled with 99mTc for Differential Diagnosis of Bone Infection of the Limbs; Bulletin of Experimental Biology and Medicine; Vol. 170, iss. 4

Radiolabeled Complex of Antimicrobial Peptides UBI29-41 and UBI18-35 Labeled with 99mTc for Differential Diagnosis of Bone Infection of the Limbs; Bulletin of Experimental Biology and Medicine; Vol. 170, iss. 4

Библиографические подробности
Источник:Bulletin of Experimental Biology and Medicine
Vol. 170, iss. 4.— 2021.— [P. 415-419]
Корпоративные авторы: Национальный исследовательский Томский политехнический университет (ТПУ) Физико-технический институт (ФТИ) Лаборатория радиационного контроля № 31 (Лаборатория РК № 31), Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий Научно-исследовательский центр "Онкотераностика"
Другие авторы: Zavadovskaya V. D. Vera Dmitrievna, Larkina M. S. Mariya Sergeevna, Stasyuk (Stasiuk) E. S. Elena Sergeyevna, Zorkaltsev M. A. Maksim Aleksandrovich, Udodov V. D. Vladimir Dmitrievich, Ivanov V. V. Vladimir Vladimirovich, Shevtsova N. M. Nataljya Mikhaylovna, Rogov A. S. Alexander Sergeyevich, Lushchik A. Ya. Aleksandr Yakovlevich, Yantsevich A. V. Aleksey Viktorovich, Belousov M. V. Mikhail Valerievich, Baykov A. N. Aleksandr Nikolaevich, Skuridin V. S. Viktor Sergeyevich, Pershina A. G. Aleksandra Gennadievna
Примечания:Title screen
We studied an original radiolabeled complex of antimicrobial peptides UBI29-41 and UBI18-35, ubiquicidin derivatives, for distinguishing between bacterial and aseptic inflammation. For radiolabeling of the peptides with technetium-99m, a bifunctional chelating agent succinimide-1-yl 6-(bis(pyridin-2-ylmethyl)amino)hexanoate was used. The obtained complexes 99mТс-DPAH-UBI29-41 and 99mТс-DPAH-UBI18-35 had radiolabeling yield >80% and radiochemical purity >96%. Accumulation of the complexes in the focus of bacterial inflammation in bone structures and the absence of this complex in the site of aseptic inflammation was confirmed in a rat model of traumatic osteomyelitis by single-photon emission computed tomography.
Режим доступа: по договору с организацией-держателем ресурса
Язык:английский
Опубликовано: 2021
Предметы:
электронный ресурс
труды учёных ТПУ
ubiquicidin
technetium-99m
osteomyelitis
SPECT
Online-ссылка:https://doi.org/10.1007/s10517-021-05078-7
Формат: Электронный ресурс Статья
Запись в KOHA:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664885
Описание
Примечания:Title screen
We studied an original radiolabeled complex of antimicrobial peptides UBI29-41 and UBI18-35, ubiquicidin derivatives, for distinguishing between bacterial and aseptic inflammation. For radiolabeling of the peptides with technetium-99m, a bifunctional chelating agent succinimide-1-yl 6-(bis(pyridin-2-ylmethyl)amino)hexanoate was used. The obtained complexes 99mТс-DPAH-UBI29-41 and 99mТс-DPAH-UBI18-35 had radiolabeling yield >80% and radiochemical purity >96%. Accumulation of the complexes in the focus of bacterial inflammation in bone structures and the absence of this complex in the site of aseptic inflammation was confirmed in a rat model of traumatic osteomyelitis by single-photon emission computed tomography.
Режим доступа: по договору с организацией-держателем ресурса
DOI:10.1007/s10517-021-05078-7

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