Radiolabeled Complex of Antimicrobial Peptides UBI29-41 and UBI18-35 Labeled with 99mTc for Differential Diagnosis of Bone Infection of the Limbs

Radiolabeled Complex of Antimicrobial Peptides UBI29-41 and UBI18-35 Labeled with 99mTc for Differential Diagnosis of Bone Infection of the Limbs

Bibliografiset tiedot
Parent link:Bulletin of Experimental Biology and Medicine
Vol. 170, iss. 4.— 2021.— [P. 415-419]
Yhteisötekijät: Национальный исследовательский Томский политехнический университет (ТПУ) Физико-технический институт (ФТИ) Лаборатория радиационного контроля № 31 (Лаборатория РК № 31), Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий Научно-исследовательский центр "Онкотераностика"
Muut tekijät: Zavadovskaya V. D. Vera Dmitrievna, Larkina M. S. Mariya Sergeevna, Stasyuk (Stasiuk) E. S. Elena Sergeyevna, Zorkaltsev M. A. Maksim Aleksandrovich, Udodov V. D. Vladimir Dmitrievich, Ivanov V. V. Vladimir Vladimirovich, Shevtsova N. M. Nataljya Mikhaylovna, Rogov A. S. Alexander Sergeyevich, Lushchik A. Ya. Aleksandr Yakovlevich, Yantsevich A. V. Aleksey Viktorovich, Belousov M. V. Mikhail Valerievich, Baykov A. N. Aleksandr Nikolaevich, Skuridin V. S. Viktor Sergeyevich, Pershina A. G. Aleksandra Gennadievna
Yhteenveto:Title screen
We studied an original radiolabeled complex of antimicrobial peptides UBI29-41 and UBI18-35, ubiquicidin derivatives, for distinguishing between bacterial and aseptic inflammation. For radiolabeling of the peptides with technetium-99m, a bifunctional chelating agent succinimide-1-yl 6-(bis(pyridin-2-ylmethyl)amino)hexanoate was used. The obtained complexes 99mТс-DPAH-UBI29-41 and 99mТс-DPAH-UBI18-35 had radiolabeling yield >80% and radiochemical purity >96%. Accumulation of the complexes in the focus of bacterial inflammation in bone structures and the absence of this complex in the site of aseptic inflammation was confirmed in a rat model of traumatic osteomyelitis by single-photon emission computed tomography.
Режим доступа: по договору с организацией-держателем ресурса
Julkaistu: 2021
Aiheet:
электронный ресурс
труды учёных ТПУ
ubiquicidin
technetium-99m
osteomyelitis
SPECT
Linkit:https://doi.org/10.1007/s10517-021-05078-7
Aineistotyyppi: Elektroninen Kirjan osa
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664885
Kuvaus
Yhteenveto:Title screen
We studied an original radiolabeled complex of antimicrobial peptides UBI29-41 and UBI18-35, ubiquicidin derivatives, for distinguishing between bacterial and aseptic inflammation. For radiolabeling of the peptides with technetium-99m, a bifunctional chelating agent succinimide-1-yl 6-(bis(pyridin-2-ylmethyl)amino)hexanoate was used. The obtained complexes 99mТс-DPAH-UBI29-41 and 99mТс-DPAH-UBI18-35 had radiolabeling yield >80% and radiochemical purity >96%. Accumulation of the complexes in the focus of bacterial inflammation in bone structures and the absence of this complex in the site of aseptic inflammation was confirmed in a rat model of traumatic osteomyelitis by single-photon emission computed tomography.
Режим доступа: по договору с организацией-держателем ресурса
DOI:10.1007/s10517-021-05078-7

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