Electrospray Preparation of Biocompatible Lactide–Glycolide Copolymer Capsules with Incorporation of Interferon

Electrospray Preparation of Biocompatible Lactide–Glycolide Copolymer Capsules with Incorporation of Interferon

Bibliographic Details
Parent link:Doklady Chemistry
Vol. 484, No. 2.— 2019.— [P. 74-78]
Corporate Authors: Национальный исследовательский Томский политехнический университет Инженерная школа природных ресурсов Отделение геологии, Национальный исследовательский Томский политехнический университет Инженерная школа ядерных технологий Отделение ядерно-топливного цикла, Национальный исследовательский Томский политехнический университет Инженерная школа ядерных технологий Научно-образовательный центр Б. П. Вейнберга
Other Authors: Khlusov I. A. Igor Albertovich, Kibler E. V. Elina Vitaljevna, Kudryavtseva V. L. Valeriya Lvovna, Tverdokhlebov S. I. Sergei Ivanovich, Bolbasov E. N. Evgeny Nikolaevich, Botvin V. V. Vladimir Viktorovich, Latypov A. D. Aleksandr Danisovich, Gatalova N. D. Natalya Dinislamovna, Litvinova L. S. Larisa Sergeevna, Buznik V. M. Vyacheslav Mikhaylovich, Choynzonov E. L. Evgeny Lkhamatsyrenovich
Summary:Title screen
The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon-?-2b (IFN?-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFN?-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules.
Режим доступа: по договору с организацией-держателем ресурса
Published: 2019
Subjects:
электронный ресурс
труды учёных ТПУ
Online Access:https://doi.org/10.1134/S0012500819020095
Format: Electronic Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664520

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