Electrospray Preparation of Biocompatible Lactide–Glycolide Copolymer Capsules with Incorporation of Interferon
| Parent link: | Doklady Chemistry Vol. 484, No. 2.— 2019.— [P. 74-78] |
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| Corporate Authors: | , , |
| Other Authors: | , , , , , , , , , , |
| Summary: | Title screen The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon-?-2b (IFN?-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFN?-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules. Режим доступа: по договору с организацией-держателем ресурса |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://doi.org/10.1134/S0012500819020095 |
| Format: | Electronic Book Chapter |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664520 |