Characterization of biomimetic silicate- and strontium-containing hydroxyapatite microparticles embedded in biodegradable electrospun polycaprolactone scaffolds for bone regeneration

Characterization of biomimetic silicate- and strontium-containing hydroxyapatite microparticles embedded in biodegradable electrospun polycaprolactone scaffolds for bone regeneration

Bibliographic Details
Parent link:	European Polymer Journal Vol. 113.— 2019.— [P. 67-77]
Corporate Author:	Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий Научно-исследовательский центр "Физическое материаловедение и композитные материалы"
Other Authors:	Surmenev R. A. Roman Anatolievich, Shkarina S. N. Svetlana Nikolaevna, Syromotina D. S. Dina Sergeevna, Melnik E. V. Elizaveta Vasilievna, Selezneva I. I. Irina Ivanovna, Ermakov A. M. Artem Mihailovich, Ivlev S. I. Sergei, Cecilia A. Angelica, Weinhardt V. Venera, Baumbach T. Tilo, Rijavec T. Tomaz, Lapanje A. Ales, Chaikina M. V. Marina Vasilevna, Surmeneva M. A. Maria Alexandrovna
Summary:	Title screen A significant need exists today to develop novel alternatives to traditional bone grafts. Here, we report the potential use of mechanochemically synthesized hydroxyapatite (HA), silicate-, or strontium-containing HA microparticles and microparticle aggregates in combination with polycaprolactone (PCL) as hybrid scaffolds for filling bone defects. The detailed characterization of scaffolds was performed with high-resolution synchrotron radiation-based microcomputed laminography, XRD, EDX, and FTIR. An in vitro cell-scaffold interaction analysis showed a significant improvement of cell spreading in the case of hybrid scaffolds with silicate- and Sr-containing HA. Scaffolds with Sr- and silicate-containing HA affected the expression of several genes involved in morphogenesis and transcription. Scaffolds with Sr-containing HA increased the expression of markers of the primary component of the extracellular matrix, and scaffolds with Sr-containing HA facilitated cell mineralization via an increase in osteocalcin production. The hybrid scaffolds with silicate- and Sr-containing HA microparticles exerted the highest antibacterial activity against gram-positive bacterium Staphylococcus aureus compared to the unmodified PCL scaffolds. Based on these findings, the obtained scaffolds with Sr- or silicate-containing HA are believed to hold promise for bone tissue regeneration as compared to scaffolds containing pure HA. Режим доступа: по договору с организацией-держателем ресурса
Published:	2019
Subjects:	электронный ресурс труды учёных ТПУ scaffold silicate-containing hydroxyapatite srontium-containing hydroxyapatite electrospinning строительные леса гидроксиапатиты электропрядение биоразлагаемые материалы регенерация кости
Online Access:	https://doi.org/10.1016/j.eurpolymj.2019.01.042
Format:	Electronic Book Chapter
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=664479

Internet

https://doi.org/10.1016/j.eurpolymj.2019.01.042