Determination of the properties and loading efficiency of encapsulated BSA-FITC and dexamethasone for drug delivery systems

Determination of the properties and loading efficiency of encapsulated BSA-FITC and dexamethasone for drug delivery systems

Bibliographische Detailangaben
Parent link:IOP Conference Series: Materials Science and Engineering
Vol. 597 : Prospects of Fundamental Sciences Development (PFSD-2019).— 2019.— [012056, 6 p.]
Körperschaft: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий Научно-исследовательский центр "Физическое материаловедение и композитные материалы"
Weitere Verfasser: Chudinova E. A. Ekaterina Aleksandrovna, Surmeneva M. A. Maria Alexandrovna, Koptyug A. V. Andrey Valentinovich, Sokolova V. Viktoriya, Primak O. Oleg, Bouckercha S., Epple M. Matthias, Surmenev R. A. Roman Anatolievich
Zusammenfassung:Title screen
In this work porous microparticles of calcium carbonate were synthesized with bovine serum albumin - fluorescein isothiocyanate conjugate (BSA-FITC) and dexamethasone, and then used for encapsulation in polymer microcapsules by means of layer-by-layer assembly (LbL). The properties of the obtained microcapsules were characterized by scanning electron microscopy, dynamic light scattering, infrared-, ultraviolet- and visible spectroscopy. According to the performed DLS measurements, an average hydrodynamic diameter ranged from 4 to 8 µm and zeta-potential for all types of capsules was determined as -18 and -21 mV. BSA-FITC was encapsulated using this approach yielded a loading efficiency of 49 % protein. This value calculated for dexamethasone was of 38%. The microcapsules filled with an encapsulated drug may find applications in the field of biotechnology, biochemistry, and medicine.
Sprache:Englisch
Veröffentlicht: 2019
Schlagworte:
электронный ресурс
труды учёных ТПУ
инкапсулированные фитоэкстракты
лекарства
Online-Zugang:https://doi.org/10.1088/1757-899X/597/1/012056
Format: Elektronisch Buchkapitel
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=662532

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