Determination of the properties and loading efficiency of encapsulated BSA-FITC and dexamethasone for drug delivery systems; IOP Conference Series: Materials Science and Engineering; Vol. 597 : Prospects of Fundamental Sciences Development (PFSD-2019)

Determination of the properties and loading efficiency of encapsulated BSA-FITC and dexamethasone for drug delivery systems; IOP Conference Series: Materials Science and Engineering; Vol. 597 : Prospects of Fundamental Sciences Development (PFSD-2019)

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Parent link:IOP Conference Series: Materials Science and Engineering
Vol. 597 : Prospects of Fundamental Sciences Development (PFSD-2019).— 2019.— [012056, 6 p.]
Korporativní autor: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий Научно-исследовательский центр "Физическое материаловедение и композитные материалы"
Další autoři: Chudinova E. A. Ekaterina Aleksandrovna, Surmeneva M. A. Maria Alexandrovna, Koptyug A. V. Andrey Valentinovich, Sokolova V. Viktoriya, Primak O. Oleg, Bouckercha S., Epple M. Matthias, Surmenev R. A. Roman Anatolievich
Shrnutí:Title screen
In this work porous microparticles of calcium carbonate were synthesized with bovine serum albumin - fluorescein isothiocyanate conjugate (BSA-FITC) and dexamethasone, and then used for encapsulation in polymer microcapsules by means of layer-by-layer assembly (LbL). The properties of the obtained microcapsules were characterized by scanning electron microscopy, dynamic light scattering, infrared-, ultraviolet- and visible spectroscopy. According to the performed DLS measurements, an average hydrodynamic diameter ranged from 4 to 8 µm and zeta-potential for all types of capsules was determined as -18 and -21 mV. BSA-FITC was encapsulated using this approach yielded a loading efficiency of 49 % protein. This value calculated for dexamethasone was of 38%. The microcapsules filled with an encapsulated drug may find applications in the field of biotechnology, biochemistry, and medicine.
Jazyk:angličtina
Vydáno: 2019
Témata:
электронный ресурс
труды учёных ТПУ
инкапсулированные фитоэкстракты
лекарства
On-line přístup:https://doi.org/10.1088/1757-899X/597/1/012056
Médium: Elektronický zdroj Kapitola
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=662532

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