Determination of the properties and loading efficiency of encapsulated BSA-FITC and dexamethasone for drug delivery systems; IOP Conference Series: Materials Science and Engineering; Vol. 597 : Prospects of Fundamental Sciences Development (PFSD-2019)
| Parent link: | IOP Conference Series: Materials Science and Engineering Vol. 597 : Prospects of Fundamental Sciences Development (PFSD-2019).— 2019.— [012056, 6 p.] |
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| Institutionell upphovsman: | |
| Övriga upphovsmän: | , , , , , , , |
| Sammanfattning: | Title screen In this work porous microparticles of calcium carbonate were synthesized with bovine serum albumin - fluorescein isothiocyanate conjugate (BSA-FITC) and dexamethasone, and then used for encapsulation in polymer microcapsules by means of layer-by-layer assembly (LbL). The properties of the obtained microcapsules were characterized by scanning electron microscopy, dynamic light scattering, infrared-, ultraviolet- and visible spectroscopy. According to the performed DLS measurements, an average hydrodynamic diameter ranged from 4 to 8 µm and zeta-potential for all types of capsules was determined as -18 and -21 mV. BSA-FITC was encapsulated using this approach yielded a loading efficiency of 49 % protein. This value calculated for dexamethasone was of 38%. The microcapsules filled with an encapsulated drug may find applications in the field of biotechnology, biochemistry, and medicine. |
| Språk: | engelska |
| Publicerad: |
2019
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| Ämnen: | |
| Länkar: | https://doi.org/10.1088/1757-899X/597/1/012056 |
| Materialtyp: | Elektronisk Bokavsnitt |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=662532 |