Determination of the properties and loading efficiency of encapsulated BSA-FITC and dexamethasone for drug delivery systems; IOP Conference Series: Materials Science and Engineering; Vol. 597 : Prospects of Fundamental Sciences Development (PFSD-2019)
| Parent link: | IOP Conference Series: Materials Science and Engineering Vol. 597 : Prospects of Fundamental Sciences Development (PFSD-2019).— 2019.— [012056, 6 p.] |
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| Ente Autore: | |
| Altri autori: | , , , , , , , |
| Riassunto: | Title screen In this work porous microparticles of calcium carbonate were synthesized with bovine serum albumin - fluorescein isothiocyanate conjugate (BSA-FITC) and dexamethasone, and then used for encapsulation in polymer microcapsules by means of layer-by-layer assembly (LbL). The properties of the obtained microcapsules were characterized by scanning electron microscopy, dynamic light scattering, infrared-, ultraviolet- and visible spectroscopy. According to the performed DLS measurements, an average hydrodynamic diameter ranged from 4 to 8 µm and zeta-potential for all types of capsules was determined as -18 and -21 mV. BSA-FITC was encapsulated using this approach yielded a loading efficiency of 49 % protein. This value calculated for dexamethasone was of 38%. The microcapsules filled with an encapsulated drug may find applications in the field of biotechnology, biochemistry, and medicine. |
| Lingua: | inglese |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://doi.org/10.1088/1757-899X/597/1/012056 |
| Natura: | MixedMaterials Elettronico Capitolo di libro |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=662532 |
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| 200 | 1 | |a Determination of the properties and loading efficiency of encapsulated BSA-FITC and dexamethasone for drug delivery systems |f E. A. Chudinova, M. A. Surmeneva, A. V. Koptyug [et al.] | |
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| 320 | |a [References: 29 tit.] | ||
| 330 | |a In this work porous microparticles of calcium carbonate were synthesized with bovine serum albumin - fluorescein isothiocyanate conjugate (BSA-FITC) and dexamethasone, and then used for encapsulation in polymer microcapsules by means of layer-by-layer assembly (LbL). The properties of the obtained microcapsules were characterized by scanning electron microscopy, dynamic light scattering, infrared-, ultraviolet- and visible spectroscopy. According to the performed DLS measurements, an average hydrodynamic diameter ranged from 4 to 8 µm and zeta-potential for all types of capsules was determined as -18 and -21 mV. BSA-FITC was encapsulated using this approach yielded a loading efficiency of 49 % protein. This value calculated for dexamethasone was of 38%. The microcapsules filled with an encapsulated drug may find applications in the field of biotechnology, biochemistry, and medicine. | ||
| 461 | 1 | |0 (RuTPU)RU\TPU\network\2008 |t IOP Conference Series: Materials Science and Engineering | |
| 463 | 1 | |0 (RuTPU)RU\TPU\network\31112 |t Vol. 597 : Prospects of Fundamental Sciences Development (PFSD-2019) |o XVI International Conference of Students and Young Scientists, 23–26 April 2019, Tomsk, Russia |o [proceedings] |f National Research Tomsk Polytechnic University (TPU) ; eds. M. E. Semenov, A. M. Bogdan |v [012056, 6 p.] |d 2019 | |
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| 701 | 1 | |a Surmeneva |b M. A. |c specialist in the field of material science |c engineer-researcher of Tomsk Polytechnic University, Associate Scientist |f 1984- |g Maria Alexandrovna |3 (RuTPU)RU\TPU\pers\31894 |9 15966 | |
| 701 | 1 | |a Koptyug |b A. V. |g Andrey Valentinovich | |
| 701 | 1 | |a Sokolova |b V. |g Viktoriya | |
| 701 | 1 | |a Primak |b O. |g Oleg | |
| 701 | 1 | |a Bouckercha |b S. | |
| 701 | 1 | |a Epple |b M. |g Matthias | |
| 701 | 1 | |a Surmenev |b R. A. |c physicist |c Associate Professor of Tomsk Polytechnic University, Senior researcher, Candidate of physical and mathematical sciences |f 1982- |g Roman Anatolievich |3 (RuTPU)RU\TPU\pers\31885 |9 15957 | |
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