pH-triggered delivery of magnetic nanoparticles depends on tumor volume; Nanomedicine: Nanotechnology, Biology and Medicine; Vol. 23

PH-triggered delivery of magnetic nanoparticles depends on tumor volume; Nanomedicine: Nanotechnology, Biology and Medicine; Vol. 23

Bibliographische Detailangaben
Parent link:Nanomedicine: Nanotechnology, Biology and Medicine
Vol. 23.— 2019.— [102086, 8 p.]
Körperschaft: Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
Weitere Verfasser: Pershina A. G. Aleksandra Gennadievna, Brikunova O. Ya. Olga Yaroslavovna, Demin A. M. Aleksandr Mikhaylovich, Shevelev O. B. Oleg Borisovich, Razumov I. A. Ivan Alekseevich, Zavjyalov E. L. Evgeny Leonidovich, Malkeeva D. Dina, Kiseleva E. V. Elena Vladimirovna, Krakhmal N. V. Nadezhda Valerjevna, Vtorushin S. V. Sergey Vladimirovich, Yarnykh V. L. Vasily, Ivanov V. V. Vladimir Vladimirovich, Pleshko R. I. Raisa Ivanovna, Krasnov V. P. Viktor Pavlovich, Ogorodova L. M. Lyudmila Mikhaylovna
Zusammenfassung:Title screen
Nowadays there is growing recognition of the fact that biological systems have a greater impact on nanoparticle target delivery in tumors than nanoparticle design. Here we investigate the targeted delivery of Fe3O4 magnetic nanoparticles conjugated with pH-low-insertion peptide (MNP-pHLIP) on orthotopically induced MDA-MB-231 human breast carcinoma xenografts of varying volumes as a model of cancer progression. Using in vivo magnetic resonance imaging and subsequent determination of iron content in tumor samples by inductively coupled plasma atomic emission spectroscopy we found that MNP-pHLIP accumulation depends on tumor volume. Transmission electron microscopy, histological analysis and immunohistochemical staining of tumor samples suggest that blood vessel distribution is the key factor in determining the success of the accumulation of nanoparticles in tumors.
Режим доступа: по договору с организацией-держателем ресурса
Sprache:Englisch
Veröffentlicht: 2019
Schlagworte:
электронный ресурс
труды учёных ТПУ
pHLIP
iron oxide magnetic nanoparticle
tumor
MRI
targeting
МРТ
опухоли
Online-Zugang:https://doi.org/10.1016/j.nano.2019.102086
Format: Elektronisch Buchkapitel
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=661660

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