pH-triggered delivery of magnetic nanoparticles depends on tumor volume

PH-triggered delivery of magnetic nanoparticles depends on tumor volume

Bibliographic Details
Parent link:	Nanomedicine: Nanotechnology, Biology and Medicine Vol. 23.— 2019.— [102086, 8 p.]
Corporate Author:	Национальный исследовательский Томский политехнический университет Исследовательская школа химических и биомедицинских технологий
Other Authors:	Pershina A. G. Aleksandra Gennadievna, Brikunova O. Ya. Olga Yaroslavovna, Demin A. M. Aleksandr Mikhaylovich, Shevelev O. B. Oleg Borisovich, Razumov I. A. Ivan Alekseevich, Zavjyalov E. L. Evgeny Leonidovich, Malkeeva D. Dina, Kiseleva E. V. Elena Vladimirovna, Krakhmal N. V. Nadezhda Valerjevna, Vtorushin S. V. Sergey Vladimirovich, Yarnykh V. L. Vasily, Ivanov V. V. Vladimir Vladimirovich, Pleshko R. I. Raisa Ivanovna, Krasnov V. P. Viktor Pavlovich, Ogorodova L. M. Lyudmila Mikhaylovna
Summary:	Title screen Nowadays there is growing recognition of the fact that biological systems have a greater impact on nanoparticle target delivery in tumors than nanoparticle design. Here we investigate the targeted delivery of Fe3O4 magnetic nanoparticles conjugated with pH-low-insertion peptide (MNP-pHLIP) on orthotopically induced MDA-MB-231 human breast carcinoma xenografts of varying volumes as a model of cancer progression. Using in vivo magnetic resonance imaging and subsequent determination of iron content in tumor samples by inductively coupled plasma atomic emission spectroscopy we found that MNP-pHLIP accumulation depends on tumor volume. Transmission electron microscopy, histological analysis and immunohistochemical staining of tumor samples suggest that blood vessel distribution is the key factor in determining the success of the accumulation of nanoparticles in tumors. Режим доступа: по договору с организацией-держателем ресурса
Published:	2019
Subjects:	электронный ресурс труды учёных ТПУ pHLIP iron oxide magnetic nanoparticle tumor MRI targeting МРТ опухоли
Online Access:	https://doi.org/10.1016/j.nano.2019.102086
Format:	Electronic Book Chapter
KOHA link:	https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=661660

Internet

https://doi.org/10.1016/j.nano.2019.102086