PH-triggered delivery of magnetic nanoparticles depends on tumor volume; Nanomedicine: Nanotechnology, Biology and Medicine; Vol. 23
| Parent link: | Nanomedicine: Nanotechnology, Biology and Medicine Vol. 23.— 2019.— [102086, 8 p.] |
|---|---|
| Autor corporatiu: | |
| Altres autors: | , , , , , , , , , , , , , , |
| Sumari: | Title screen Nowadays there is growing recognition of the fact that biological systems have a greater impact on nanoparticle target delivery in tumors than nanoparticle design. Here we investigate the targeted delivery of Fe3O4 magnetic nanoparticles conjugated with pH-low-insertion peptide (MNP-pHLIP) on orthotopically induced MDA-MB-231 human breast carcinoma xenografts of varying volumes as a model of cancer progression. Using in vivo magnetic resonance imaging and subsequent determination of iron content in tumor samples by inductively coupled plasma atomic emission spectroscopy we found that MNP-pHLIP accumulation depends on tumor volume. Transmission electron microscopy, histological analysis and immunohistochemical staining of tumor samples suggest that blood vessel distribution is the key factor in determining the success of the accumulation of nanoparticles in tumors. Режим доступа: по договору с организацией-держателем ресурса |
| Idioma: | anglès |
| Publicat: |
2019
|
| Matèries: | |
| Accés en línia: | https://doi.org/10.1016/j.nano.2019.102086 |
| Format: | Electrònic Capítol de llibre |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=661660 |
MARC
| LEADER | 00000naa0a2200000 4500 | ||
|---|---|---|---|
| 001 | 661660 | ||
| 005 | 20250417114706.0 | ||
| 035 | |a (RuTPU)RU\TPU\network\32384 | ||
| 035 | |a RU\TPU\network\14181 | ||
| 090 | |a 661660 | ||
| 100 | |a 20200127d2019 k||y0rusy50 ba | ||
| 101 | 0 | |a eng | |
| 135 | |a drcn ---uucaa | ||
| 181 | 0 | |a i | |
| 182 | 0 | |a b | |
| 200 | 1 | |a pH-triggered delivery of magnetic nanoparticles depends on tumor volume |f A. G. Pershina [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 30 tit.] | ||
| 330 | |a Nowadays there is growing recognition of the fact that biological systems have a greater impact on nanoparticle target delivery in tumors than nanoparticle design. Here we investigate the targeted delivery of Fe3O4 magnetic nanoparticles conjugated with pH-low-insertion peptide (MNP-pHLIP) on orthotopically induced MDA-MB-231 human breast carcinoma xenografts of varying volumes as a model of cancer progression. Using in vivo magnetic resonance imaging and subsequent determination of iron content in tumor samples by inductively coupled plasma atomic emission spectroscopy we found that MNP-pHLIP accumulation depends on tumor volume. Transmission electron microscopy, histological analysis and immunohistochemical staining of tumor samples suggest that blood vessel distribution is the key factor in determining the success of the accumulation of nanoparticles in tumors. | ||
| 333 | |a Режим доступа: по договору с организацией-держателем ресурса | ||
| 461 | |t Nanomedicine: Nanotechnology, Biology and Medicine | ||
| 463 | |t Vol. 23 |v [102086, 8 p.] |d 2019 | ||
| 610 | 1 | |a электронный ресурс | |
| 610 | 1 | |a труды учёных ТПУ | |
| 610 | 1 | |a pHLIP | |
| 610 | 1 | |a iron oxide magnetic nanoparticle | |
| 610 | 1 | |a tumor | |
| 610 | 1 | |a MRI | |
| 610 | 1 | |a targeting | |
| 610 | 1 | |a МРТ | |
| 610 | 1 | |a опухоли | |
| 701 | 1 | |a Pershina |b A. G. |c biologist |c Associate Professor of Tomsk Polytechnic University, Candidate of biological sciences |f 1981- |g Aleksandra Gennadievna |3 (RuTPU)RU\TPU\pers\32466 |9 16414 | |
| 701 | 1 | |a Brikunova |b O. Ya. |g Olga Yaroslavovna | |
| 701 | 1 | |a Demin |b A. M. |g Aleksandr Mikhaylovich | |
| 701 | 1 | |a Shevelev |b O. B. |g Oleg Borisovich | |
| 701 | 1 | |a Razumov |b I. A. |g Ivan Alekseevich | |
| 701 | 1 | |a Zavjyalov |b E. L. |g Evgeny Leonidovich | |
| 701 | 1 | |a Malkeeva |b D. |g Dina | |
| 701 | 1 | |a Kiseleva |b E. V. |g Elena Vladimirovna | |
| 701 | 1 | |a Krakhmal |b N. V. |g Nadezhda Valerjevna | |
| 701 | 1 | |a Vtorushin |b S. V. |g Sergey Vladimirovich | |
| 701 | 1 | |a Yarnykh |b V. L. |g Vasily | |
| 701 | 1 | |a Ivanov |b V. V. |g Vladimir Vladimirovich | |
| 701 | 1 | |a Pleshko |b R. I. |g Raisa Ivanovna | |
| 701 | 1 | |a Krasnov |b V. P. |g Viktor Pavlovich | |
| 701 | 1 | |a Ogorodova |b L. M. |g Lyudmila Mikhaylovna | |
| 712 | 0 | 2 | |a Национальный исследовательский Томский политехнический университет |b Исследовательская школа химических и биомедицинских технологий |c (2017- ) |3 (RuTPU)RU\TPU\col\23537 |
| 801 | 2 | |a RU |b 63413507 |c 20200127 |g RCR | |
| 850 | |a 63413507 | ||
| 856 | 4 | |u https://doi.org/10.1016/j.nano.2019.102086 | |
| 942 | |c CF | ||