Quantitative determination of new anti-inflammatory drug indomenthyl and its metabolite in rabbit plasma by HPLC-MS/MS; Analytical Methods; Vol. 13, iss. 41

Quantitative determination of new anti-inflammatory drug indomenthyl and its metabolite in rabbit plasma by HPLC-MS/MS

Bibliografiske detaljer
Parent link:Analytical Methods
Vol. 13, iss. 41.— 2021.— [9 p.]
Institution som forfatter: Национальный исследовательский Томский политехнический университет Инженерная школа природных ресурсов Отделение химической инженерии
Andre forfattere: Leonov K. A. Klim Andreevich, Bykova A. V. Arina Vladimirovna, Bykov V. V. Vladimir Valerjevich, Vishenkova D. A. Dariya Aleksandrovna, Lipskikh O. I. Olga Ivanovna, Dorozhko E. V. Elena Vladimirovna, Pavlovsky V. I. Viktor Ivanovich, Vengerovsky A. I. Aleksandr Isaakovich, Udut V. V. Vladimir Vasiljevich
Summary:Title screen
Background: Indomenthyl is an innovative anti-inflammatory drug with a high analgesic activity. Indomenthyl releases indomethacin under the influence of neutrophil esterases in the inflammation focus. Methodology/results: This research is aimed at developing a highly sensitive method for the quantitative determination of indomenthyl and its active metabolite indomethacin in rabbit plasma by HPLC-MS/MS. Protein precipitation and extraction with acetonitrile were used for analyte isolation from plasma according to the QuEChERS principle. The target quantitative ion pairs m/z were respectively 496.4 / 358.0 for indomenthyl, 358.0 / 139.5 for indomethacin, and 340.1 / 202.1 for the IS. Conclusion: The calibration curve was linear over the range 0.1-1000 ng mL1 . The technique was applied to the pharmacokinetic study at a dose of 25 mg kg1 to rabbits
Sprog:engelsk
Udgivet: 2021
Fag:
электронный ресурс
труды учёных ТПУ
Online adgang:https://doi.org/10.1039/D1AY01220G
Format: Electronisk Book Chapter
KOHA link:https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=657605

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