Quantitative determination of new anti-inflammatory drug indomenthyl and its metabolite in rabbit plasma by HPLC-MS/MS
| Parent link: | Analytical Methods Vol. 13, iss. 41.— 2021.— [9 p.] |
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| Համատեղ հեղինակ: | |
| Այլ հեղինակներ: | , , , , , , , , |
| Ամփոփում: | Title screen Background: Indomenthyl is an innovative anti-inflammatory drug with a high analgesic activity. Indomenthyl releases indomethacin under the influence of neutrophil esterases in the inflammation focus. Methodology/results: This research is aimed at developing a highly sensitive method for the quantitative determination of indomenthyl and its active metabolite indomethacin in rabbit plasma by HPLC-MS/MS. Protein precipitation and extraction with acetonitrile were used for analyte isolation from plasma according to the QuEChERS principle. The target quantitative ion pairs m/z were respectively 496.4 / 358.0 for indomenthyl, 358.0 / 139.5 for indomethacin, and 340.1 / 202.1 for the IS. Conclusion: The calibration curve was linear over the range 0.1-1000 ng mL1 . The technique was applied to the pharmacokinetic study at a dose of 25 mg kg1 to rabbits |
| Հրապարակվել է: |
2021
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| Խորագրեր: | |
| Առցանց հասանելիություն: | https://doi.org/10.1039/D1AY01220G |
| Ձևաչափ: | Էլեկտրոնային Գրքի գլուխ |
| KOHA link: | https://koha.lib.tpu.ru/cgi-bin/koha/opac-detail.pl?biblionumber=657605 |
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| 200 | 1 | |a Quantitative determination of new anti-inflammatory drug indomenthyl and its metabolite in rabbit plasma by HPLC-MS/MS |f K. A. Leonov, A. V. Bykova, V. V. Bykov [et al.] | |
| 203 | |a Text |c electronic | ||
| 300 | |a Title screen | ||
| 320 | |a [References: 24 tit.] | ||
| 330 | |a Background: Indomenthyl is an innovative anti-inflammatory drug with a high analgesic activity. Indomenthyl releases indomethacin under the influence of neutrophil esterases in the inflammation focus. Methodology/results: This research is aimed at developing a highly sensitive method for the quantitative determination of indomenthyl and its active metabolite indomethacin in rabbit plasma by HPLC-MS/MS. Protein precipitation and extraction with acetonitrile were used for analyte isolation from plasma according to the QuEChERS principle. The target quantitative ion pairs m/z were respectively 496.4 / 358.0 for indomenthyl, 358.0 / 139.5 for indomethacin, and 340.1 / 202.1 for the IS. Conclusion: The calibration curve was linear over the range 0.1-1000 ng mL1 . The technique was applied to the pharmacokinetic study at a dose of 25 mg kg1 to rabbits | ||
| 461 | |t Analytical Methods | ||
| 463 | |t Vol. 13, iss. 41 |v [9 p.] |d 2021 | ||
| 610 | 1 | |a электронный ресурс | |
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| 701 | 1 | |a Leonov |b K. A. |g Klim Andreevich | |
| 701 | 1 | |a Bykova |b A. V. |g Arina Vladimirovna | |
| 701 | 1 | |a Bykov |b V. V. |g Vladimir Valerjevich | |
| 701 | 1 | |a Vishenkova |b D. A. |c chemist |c engineer of Tomsk Polytechnic University |f 1989- |g Dariya Aleksandrovna |3 (RuTPU)RU\TPU\pers\33918 | |
| 701 | 1 | |a Lipskikh |b O. I. |c chemist |c engineer of Tomsk Polytechnic University |f 1984- |g Olga Ivanovna |3 (RuTPU)RU\TPU\pers\38489 | |
| 701 | 1 | |a Dorozhko |b E. V. |c chemist |c Engineer of Tomsk Polytechnic University |f 1979- |g Elena Vladimirovna |3 (RuTPU)RU\TPU\pers\32174 |9 16175 | |
| 701 | 1 | |a Pavlovsky |b V. I. |c chemist |c Professor of Tomsk Polytechnic University, Doctor of chemical sciences |f 1958- |g Viktor Ivanovich |3 (RuTPU)RU\TPU\pers\46884 | |
| 701 | 1 | |a Vengerovsky |b A. I. |g Aleksandr Isaakovich | |
| 701 | 1 | |a Udut |b V. V. |g Vladimir Vasiljevich | |
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